ArticleNPJ Parkinson's disease2022
Neuropathology of Parkinson's disease after focused ultrasound thalamotomy.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- MRI-Guided Focused Ultrasound in Parkinson's Disease and Essential Tremor: Incisionless but Invasive. A Narrative Review.Journal of movement disorders · 2025Article
- Optimal focused ultrasound lesion location in essential tremor.Science advances · 2025Article
- Postmortem Analysis 35 Months after Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Focused Ultrasound Thalamotomy: Correlation of Postoperative Imaging with Neuropathological Findings.Stereotactic and functional neurosurgery · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focused ultrasound (FUS) thalamotomy is an emerging treatment for tremor-dominant Parkinson's disease (PD). We report the first postmortem neuropathologic study of FUS thalamotomy in a 68-year-old man with tremor-dominant PD, which was performed seven months before he died. Although the peak voxel temperature at the target was <54 °C, his tremor improved on intraoperative and postoperative assessments. Additionally, postoperative MRI demonstrated a thalamic lesion. Lewy body-related pathology consistent with PD was detected. There was also a 5-mm lesion in the ventral lateral thalamus characterized by demyelination and neuropil loss, with many lipid-laden macrophages, but no lymphocytic infiltrates and relatively preserved neurons and axons. Additional pathological assessments after FUS thalamotomy are needed to determine if the observed brain changes are typical of this procedure.
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Registered trials
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