ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022
Impact of right ventricular-pulmonary arterial coupling on clinical outcomes of tricuspid regurgitation.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Right ventricular function-pulmonary pressure interaction as a predictor of mortality in tricuspid regurgitation.The international journal of cardiovascular imaging · 2026Article
- Tricuspid valve disease: updates on diagnostic imaging and intervention.Nature reviews. Cardiology · 2026Review
- Indication and timing in tricuspid interventions.Journal of echocardiography · 2025Review
- The prognostic value of the Dandel's index in patients undergoing tricuspid transcatheter edge-to-edge repair.European journal of heart failure · 2025Article
- Transcatheter Tricuspid Valve Intervention in Right Heart Failure: Tailored Treatment Strategies.JACC. Asia · 2025Article
- Application of an echocardiographic index to characterize right ventricular-pulmonary arterial coupling in heart failure.ESC heart failure · 2024Review
- Refining accuracy of RV-PA coupling in patients undergoing transcatheter tricuspid valve treatment.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Edge-to-Edge Repair for Tricuspid Valve Regurgitation. Preliminary Echo-Data and Clinical Implications from the Tricuspid Regurgitation IMAging (TRIMA) Study.Journal of clinical medicine · 2022Article
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn terms of pathophysiology, tricuspid regurgitation (TR) and right ventricular (RV) function are linked to each other.
aimsThis study sought to evaluate RV-pulmonary artery (PA) coupling and its impact on clinical outcomes of TR in patients undergoing mitral transcatheter edge-to-edge repair (TEER).
methodsWe calculated RV-PA coupling ratios in patients undergoing mitral TEER from August 2010 to March 2019 by dividing the tricuspid annular plane systolic excursion (TAPSE) by the echocardiographic estimated PA systolic pressure (PASP). TR was graded as none/trace, mild, moderate, or severe. The primary outcome was all-cause mortality or rehospitalisation within 12 months.
resultsAmong 744 patients analysed, severe TR was documented in 22.3% of patients and the mean TAPSE/PASP was 0.43±0.25. Technical success of TEER was achieved in 97.2% of participants. Severe TR vs TR ≤moderate (adjusted HR 1.92, 95% CI: 1.39-2.66) and TAPSE/PASP (adjusted HR 0.45, 95% CI: 0.22-0.93) were associated with the outcome. Patients were divided according to the TAPSE/PASP tertile. Compared to patients with TR ≤moderate, patients with severe TR had a higher event rate (TAPSE/PASP <0.30: 32.9% vs 45.1%; 0.30≤ TAPSE/PASP <0.44: 27.8% vs 41.8%; TAPSE/PASP ≥0.44: 16.0% vs 40.4%), whereas the prognostic significance of TR was attenuated in patients with reduced TAPSE/PASP (i.e., RV-PA uncoupling; interaction term p=0.03). The trends were consistent in the multivariable regression models, spline curves, and sensitivity analysis using post-interventional parameters.
conclusionsRV-PA coupling affects the outcome correlation of TR in patients undergoing mitral TEER. The prognostic impact of TR is attenuated in patients with RV-PA uncoupling.
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