ArticleBMC complementary medicine and therapies2022
Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities.
Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Beyond the mouse: organoids, spheroids, and organs-on-chips as the (inevitable) future of malaria research?Malaria journal · 2026Review
- Nano-Enabled Herbal Remedies for Malaria Treatment: A Review of Recent Advances.Life (Basel, Switzerland) · 2026Review
- Antimalarial Activity of Aqueous Extracts of Nasturtium (Molecules (Basel, Switzerland) · 2024Article
- Acaricidal activity of Egyptian crude plant extracts against Haemaphysalis longicornis ticks.PloS one · 2024Article
- Review
- Knowledge about Asymptomatic Malaria and Acceptability of UsingInternational journal of environmental research and public health · 2023Article
- Pharmacological Properties of Four Plant Species of the GenusMolecules (Basel, Switzerland) · 2023Review
- Secondary Metabolites Isolated fromMetabolites · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMedicinal plants have been successfully used as an alternative source of drugs for the treatment of microbial diseases. Finding a novel treatment for malaria is still challenging, and various extracts from different wild desert plants have been reported to have multiple medicinal uses for human public health, this study evaluated the antimalarial efficacy of several Egyptian plant extracts.
methodsWe assessed the cytotoxic potential of 13 plant extracts and their abilities to inhibit the in vitro growth of Plasmodium falciparum (3D7), and to treat infection with non-lethal Plasmodium yoelii 17XNL in an in vivo malaria model in BALB/c mice.
resultsIn vitro screening identified four promising candidates, Trichodesma africanum, Artemisia judaica, Cleome droserifolia, and Vachellia tortilis, with weak-to-moderate activity against P. falciparum erythrocytic blood stages with mean half-maximal inhibitory concentration 50 (IC
conclusionOur study identified novel natural antimalarial agents of plant origin that have potential for development into therapeutics for treating malaria.
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Registered trials
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