Evidence map›Paper›PMID 35550080›Full record

ArticleThe Lancet. Planetary health2022

Global, regional, and national burden of mortality associated with short-term temperature variability from 2000-19: a three-stage modelling study.

Yao Wu, Shanshan Li, Qi Zhao, Bo Wen, Antonio Gasparrini, Shilu Tong, Ala Overcenco, Aleš Urban, Alexandra Schneider, Alireza Entezari and 57 more

Abstract read
In one paragraph

Article in The Lancet. Planetary health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Building the model: a review of input structures in extreme temperature-health.Environmental health : a global access science source · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

67 authors.

Yao WuDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Shanshan LiDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Electronic address: shanshan.li@monash.edu.
Qi ZhaoDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Bo WenDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Antonio GasparriniDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK; Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, UK; Centre on Climate Change & Planetary Health, London School of Hygiene & Tropical Medicine, London, UK.
Shilu TongShanghai Children's Medical Centre, Shanghai Jiao Tong University, Shanghai, China; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China; Center for Global Health, Nanjing Medical University, Nanjing, China; School of Public Health and Social Work, Queensland University of Technology, Brisbane, QLD, Australia.
Ala OvercencoNational Agency for Public Health of the Ministry of Health, Labour and Social Protection of the Republic of Moldova, Chișinău, Moldova.
Aleš UrbanInstitute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
Alexandra SchneiderInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Alireza EntezariFaculty of Geography and Environmental Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Ana Maria Vicedo-CabreraDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Oeschger Center for Climate Change Research, University of Bern, Bern, Switzerland.
Antonella ZanobettiDepartment of Environmental Health, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Antonis AnalitisDepartment of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece.
Ariana ZekaInstitute for Environment, Health and Societies, Brunel University London, London, UK.
Aurelio TobiasInstitute of Environmental Assessment and Water Research, Spanish Council for Scientific Research, Barcelona, Spain; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Baltazar NunesDepartment of Epidemiology, Instituto Nacional de Saúde Dr Ricardo Jorge, Porto, Portugal; Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa, Lisbon, Portugal.
Barrak AlahmadDepartment of Environmental Health, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Ben ArmstrongDepartment of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Bertil ForsbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Shih-Chun PanNationalInstitute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan.
Carmen ÍñiguezDepartment of Statistics and Computational Research, Universitat de València, València, Spain; CIBER of Epidemiology and Public Health, Madrid, Spain.
Caroline AmelingNational Institute for Public Health and the Environment (RIVM), Centre for Sustainability and Environmental Health, Bilthoven, Netherlands.
César De la Cruz ValenciaDepartment of Environmental Health, National Institute of Public Health, Cuernavaca Morelos, Mexico.
Christofer ÅströmDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Danny HouthuijsNational Institute for Public Health and the Environment (RIVM), Centre for Sustainability and Environmental Health, Bilthoven, Netherlands.
Do Van DungDepartment of Environmental Health, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Dominic RoyéCIBER of Epidemiology and Public Health, Madrid, Spain; Department of Geography, University of Santiago de Compostela, Santiago de Compostela, Spain.
Ene IndermitteInstitute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Eric LavigneSchool of Epidemiology & Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Air Health Science Division, Health Canada, Ottawa, ON, Canada.
Fatemeh MayvanehFaculty of Geography and Environmental Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Fiorella AcquaottaDepartment of Earth Sciences, University of Torino, Turin, Italy.
Francesca de'DonatoDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Shilpa RaoNorwegian Institute of Public Health, Oslo, Norway.
Francesco SeraDepartment of Statistics, Computer Science and Applications "G Parenti", University of Florence, Florence, Italy.
Gabriel Carrasco-EscobarHealth Innovation Lab, Institute of Tropical Medicine "Alexander von Humboldt", Universidad Peruana Cayetano Heredia, Lima, Peru; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.
Haidong KanDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai, China.
Hans OrruInstitute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Ho KimGraduate School of Public Health, Seoul National University, Seoul, South Korea.
Iulian-Horia HolobacaFaculty of Geography, Babeş-Bolyai University, Cluj-Napoca, Romania.
Jan KyselýInstitute of Atmospheric Physics, Czech Academy of Sciences, Prague, Czech Republic; Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic.
Joana MadureiraEnvironmental Health Department, Instituto Nacional de Saúde Dr Ricardo Jorge, Porto, Portugal; EPIUnit-Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal.
Joel SchwartzDepartment of Environmental Health, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA.
Jouni J K JaakkolaCenter for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland.
Klea KatsouyanniDepartment of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece; School of Population Health and Environmental Sciences, King's College London, London, UK.
Magali Hurtado DiazDepartment of Environmental Health, National Institute of Public Health, Cuernavaca Morelos, Mexico.
Martina S RagettliSwiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Masahiro HashizumeDepartment of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mathilde PascalSanté Publique France, Department of Environmental and Occupational Health, French National Public Health Agency, Saint Maurice, France.
Micheline de Sousa Zanotti Stagliorio CoélhoDepartment of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Nicolás Valdés OrtegaDepartment of Public Health, Universidad de los Andes, Santiago, Chile.
Niilo RytiCenter for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland; Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland.
Noah ScovronickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Paola MichelozziDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Patricia Matus CorreaDepartment of Public Health, Universidad de los Andes, Santiago, Chile.
Patrick GoodmanSchool of Physics, Technological University Dublin, Dublin, Ireland.
Paulo Hilario Nascimento SaldivaINSPER, São Paulo, Brazil.
Rosana AbrutzkyUniversidad de Buenos Aires, Facultad de Ciencias Sociales, Instituto de Investigaciones Gino Germani, Buenos Aires, Argentina.
Samuel OsorioDepartment of Environmental Health, University of São Paulo, São Paulo, Brazil.
Tran Ngoc DangDepartment of Environmental Health, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Valentina ColistroDepartment of Quantitative Methods, School of Medicine, University of the Republic, Montevideo, Uruguay.
Veronika HuberIBE-Chair of Epidemiology, LMU Munich, Munich, Germany; Department of Physical, Chemical and Natural Systems, Universidad Pablo de Olavide, Sevilla, Spain.
Whanhee LeeSchool of the Environment, Yale University, New Haven, CT, USA; Department of Occupational and Environmental Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea.
Xerxes SeposoSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Yasushi HondaCenter for Climate Change Adaptation, National Institute for Environmental Studies, Tsukuba, Japan.
Yue Leon GuoNationalInstitute of Environmental Health Science, National Health Research Institutes, Zhunan, Taiwan; Environmental and Occupational Medicine, National Taiwan University College of Medicine and NTU Hospital, National Taiwan University, Taipei, Taiwan; Graduate Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, National Taiwan University, Taipei, Taiwan.
Michelle L BellSchool of the Environment, Yale University, New Haven, CT, USA.
Yuming GuoDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Electronic address: yuming.guo@monash.edu.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Medical Research Council MR/R013349/1NIEHS NIH HHS P30 ES019776
6 · The paper itself

Abstract

backgroundIncreased mortality risk is associated with short-term temperature variability. However, to our knowledge, there has been no comprehensive assessment of the temperature variability-related mortality burden worldwide. In this study, using data from the MCC Collaborative Research Network, we first explored the association between temperature variability and mortality across 43 countries or regions. Then, to provide a more comprehensive picture of the global burden of mortality associated with temperature variability, global gridded temperature data with a resolution of 0·5° × 0·5° were used to assess the temperature variability-related mortality burden at the global, regional, and national levels. Furthermore, temporal trends in temperature variability-related mortality burden were also explored from 2000-19.

methodsIn this modelling study, we applied a three-stage meta-analytical approach to assess the global temperature variability-related mortality burden at a spatial resolution of 0·5° × 0·5° from 2000-19. Temperature variability was calculated as the SD of the average of the same and previous days' minimum and maximum temperatures. We first obtained location-specific temperature variability related-mortality associations based on a daily time series of 750 locations from the Multi-country Multi-city Collaborative Research Network. We subsequently constructed a multivariable meta-regression model with five predictors to estimate grid-specific temperature variability related-mortality associations across the globe. Finally, percentage excess in mortality and excess mortality rate were calculated to quantify the temperature variability-related mortality burden and to further explore its temporal trend over two decades.

findingsAn increasing trend in temperature variability was identified at the global level from 2000 to 2019. Globally, 1 753 392 deaths (95% CI 1 159 901-2 357 718) were associated with temperature variability per year, accounting for 3·4% (2·2-4·6) of all deaths. Most of Asia, Australia, and New Zealand were observed to have a higher percentage excess in mortality than the global mean. Globally, the percentage excess in mortality increased by about 4·6% (3·7-5·3) per decade. The largest increase occurred in Australia and New Zealand (7·3%, 95% CI 4·3-10·4), followed by Europe (4·4%, 2·2-5·6) and Africa (3·3, 1·9-4·6).

interpretationGlobally, a substantial mortality burden was associated with temperature variability, showing geographical heterogeneity and a slightly increasing temporal trend. Our findings could assist in raising public awareness and improving the understanding of the health impacts of temperature variability.

fundingAustralian Research Council, Australian National Health & Medical Research Council.

Indexed as

BiodiversityGlobal HealthAustraliaCitiesFemaleHumansPregnancyTemperature

Identifiers

PMID35550080
PMCPMC9177161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.