Evidence map›Paper›PMID 35550013›Full record

ReviewJournal of animal science and biotechnology2022

The health benefits of selenium in food animals: a review.

Brittany M Pecoraro, Diego F Leal, Alba Frias-De-Diego, Matthew Browning, Jack Odle, Elisa Crisci

Open access · goldAbstract readReview
In one paragraph

Review in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication.Apoptosis : an international journal on programmed cell death · 2026
    Review
  6. Article
  7. Article
  8. Selenium Content of the Gonads of the Domestic Dog (Animals : an open access journal from MDPI · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brittany M PecoraroCollege of Veterinary Medicine, Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA.
Diego F LealCollege of Veterinary Medicine, Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA.
Alba Frias-De-DiegoCollege of Veterinary Medicine, Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA.
Matthew BrowningCollege of Veterinary Medicine, Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA.
Jack OdleLaboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA.
Elisa CrisciCollege of Veterinary Medicine, Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina, USA. ecrisci@ncsu.edu.ORCID http://orcid.org/0000-0002-4235-8508
North Carolina State University · US

Funding

USDA National Institute of Food and Agriculture, Hatch project 1016618
6 · The paper itself

Abstract

Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and humans. It evinces a strong antioxidant, anti-inflammatory and potential antimicrobial capacity. Selenium biological function is primarily achieved by its presence in selenoproteins as a form of selenocysteine. Selenium deficiency may result in an array of health disorders, affecting many organs and systems; to prevent this, dietary supplementation, mainly in the forms of organic (i.e., selenomethionine and selenocysteine) inorganic (i.e., selenate and selenite) sources is used. In pigs as well as other food animals, dietary selenium supplementation has been used for improving growth performance, immune function, and meat quality. A substantial body of knowledge demonstrates that dietary selenium supplementation is positively associated with overall animal health especially due to its immunomodulatory activity and protection from oxidative damage. Selenium also possesses potential antiviral activity and this is achieved by protecting immune cells against oxidative damage and decreasing viral replication. In this review we endeavor to combine established and novel knowledge on the beneficial effects of dietary selenium supplementation, its antioxidant and immunomodulatory actions, and the putative antimicrobial effect thereof. Furthermore, our review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral, underscoring the need for further in vivo and in vitro studies, particularly in pigs.

Indexed as

AntimicrobialAntioxidantFood animalsImmunomodulationPigSelenium

Identifiers

PMID35550013
PMCPMC9101896
OpenAlexW4280585197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.