ArticleTrials2022
Success and failure factors of patient recruitment for industry-sponsored clinical trials and the role of the electronic health records-a qualitative interview study in the Nordic countries.
Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Participation and Refusal in an Implementation Trial: Insights from the Accelerating Cervical Cancer Elimination through the Integration of Screen-and-Treat Services (ACCESS) Study.Research square · 2026Article
- Clinical research in private hospitals: a perspective.Journal of translational medicine · 2026Review
- Finding trials for participants: an ethnographic study of successful recruitment strategies for clinical trials.Trials · 2025Article
- Taxonomy of chronic illness research recruitment: a restricted scoping review.BMC health services research · 2025Article
- Ethical and academic dilemmas in authorship of clinical research publications: a medical oncologist's perspective.Medical oncology (Northwood, London, England) · 2025Review
- Phase 1 Clinical Trials: Challenges and Opportunities in Latin America.Journal of immunotherapy and precision oncology · 2024Article
- Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis.Contemporary clinical trials communications · 2024Article
- Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data.Clinical and translational science · 2023Article
- Electronic health records in Romania - window of opportunity in improving population's health?Journal of medicine and life · 2022Article
- Sarcoidosis: Updates on therapeutic drug trials and novel treatment approaches.Frontiers in medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPatient recruitment for clinical trials is challenging-only approximately one third of all trials recruit their participants as planned. The pharmaceutical industry's views on recruitment success have not been comprehensively investigated, although the industry globally conducts almost one third of all clinical drug trials. This study explored patient recruitment success and failure factors and the role of electronic health records (EHR) in the recruitment of trial participants in the Nordic countries.
methodsA descriptive qualitative interview study was conducted with 21 representatives of the pharmaceutical industry or contract research organizations operating in Finland, Sweden, Denmark, and Norway. The interviews covered 34 clinical pre-market drug trials. Qualitative data were analyzed using inductive content analysis.
resultsFour main categories were derived to represent both success and failure factors, whereas a fifth category represented only failure factors: (1) sponsor-related (protocol and trial preparation and feasibility evaluations), (2) site/investigator-related (access to patients, motivation, commitment and resources), (3) patient-related recruitment factors (medical need, patients' role in their care and attitudes towards trials), (4) Sponsor-sites-patients collaboration factors, and (5) start-up related factors. EHR was the most important source of recruitment, utilized in 29 out of 34 trials discussed. Revision of the legislation regulating the secondary use of EHR was highlighted as the most effective measure to facilitate the use of EHR in recruitment of trial participants.
conclusionsThe industry representatives recognized quite well their own role in contributing to the success or failure of the recruitment: to facilitate recruitment of trial participants, many obstacles can be avoided with better trial preparation and proper feasibility evaluations. As access to patients represents one of the key success or failure factors of recruitment, and as the EHR is regarded the main source of searching for and finding patients, the development of EHR utilization appears to represent a powerful tool to improve patient recruitment.
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