Trial reportAmerican journal of respiratory and critical care medicine2022
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes.
Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine learning for prediction of asthma exacerbations among asthmatic patients: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- Trial
- Type 2-low Asthma: Epidemiology, Multiomics, and Emerging Therapies.Current allergy and asthma reports · 2026Review
- Clinical utility of sputum cytology in severe asthma: insights from a specialist centre.ERJ open research · 2026Article
- Cathepsin C orchestrates RSV-induced asthma exacerbation through the dual effect of monocyte-derived macrophages.Cellular & molecular immunology · 2026Article
- Risk Factors for COVID-19 mRNA Vaccine-Associated Exacerbations in Patients With Obstructive Airway Diseases: REsearch for Asthma and COPD ExacerbaTION Caused by COVID-19 mRNA Vaccination (REACTION Study).Allergy, asthma & immunology research · 2026Article
- Systemic-airway eosinophil discordance and sputum mediator profiling in severe asthma treated with biologics: a retrospective cohort study.BMC pulmonary medicine · 2026Article
- Asthma management in pregnancy and lactation: A review of current evidence and best practice recommendations.NPJ primary care respiratory medicine · 2026Review
- Review
- Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma.Antibodies (Basel, Switzerland) · 2025Review
- Next Decade Research in Asthma: Broad Omics-Based Exploration Versus Targeted Airway Epithelium Studies.Journal of clinical medicine · 2025Review
- The Risk-Benefit Balance of Oral Corticosteroid Treatment for Asthma Attacks: A Discrete Choice Experiment of Patients and Healthcare Professionals in the UK and New Zealand.Respirology (Carlton, Vic.) · 2025Article
- Fractional exhaled nitric oxide and the response to prednisolone for asthma attacks in patients treated with anti-IL5/5Rα therapy: a prospective observational study.The European respiratory journal · 2025Article
- Machine learning reveals limited predictive value of clinical factors for asthma exacerbations.Scientific reports · 2025Article
- Unraveling the mechanisms of virus-induced asthma exacerbation: epithelial injury, immune dysregulation, and novel interventions.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates.CHEST pulmonary · 2025Article
- Circadian Clock Disruption and Non-type 2 Asthma: A Hypothesis-Driven Perspective on Immune, Epithelial, and Steroid Response.Clinical reviews in allergy & immunology · 2025Review
- Predictors of asthma exacerbation between high and low blood eosinophil counts.ERJ open research · 2025Article
- Differential Analysis of Hemogram Parameters and Cellular Ratios in Severe Asthma Exacerbations: A Comparative Study of Eosinophilic and Non-Eosinophilic Phenotypes.Life (Basel, Switzerland) · 2025Article
Corrections and comments
- Commented on by
Authors and funding
25 authors.
P Jane McDowellCenter for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom.ORCID 0000-0003-2063-7992
John BusbyCenter for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom.
Catherine E HanrattyCenter for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom.ORCID 0000-0003-2453-6021
Ratko DjukanovicSchool of Clinical and Experimental Sciences, University of Southampton, National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Center, Southampton, United Kingdom.ORCID 0000-0001-6039-5612
Ashley WoodcockManchester Academic Health Science Center and NIHR Manchester Biomedical Research Center, Manchester University Hospitals National Health Service (NHS) Foundation Trust, Manchester, United Kingdom.ORCID 0000-0002-5428-8578
Samantha WalkerAsthma UK and British Lung Foundation Partnership, London, United Kingdom.
Timothy Colin HardmanNiche Science and Technology Ltd., Richmond, United Kingdom.ORCID 0000-0002-1417-9019
Joseph R ArronGenentech Inc., San Francisco, California.ORCID 0000-0001-7677-9979
David F ChoyGenentech Inc., San Francisco, California.
Peter BraddingDepartment of Respiratory Sciences, Institute for Lung Health and Leicester NIHR Biomedical Research Center, University of Leicester, Leicester, United Kingdom.ORCID 0000-0001-8403-0319
Chris E BrightlingDepartment of Respiratory Sciences, Institute for Lung Health and Leicester NIHR Biomedical Research Center, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-9345-4903
Rekha ChaudhuriGartnavel General Hospital, Glasgow and University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-8007-949X
Douglas CowanNHS Greater Glasgow and Clyde, Stobhill Hospital, Glasgow, United Kingdom.
Adel H MansurUniversity of Birmingham and Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.ORCID 0000-0002-8615-8778
Stephen J FowlerManchester Academic Health Science Center and NIHR Manchester Biomedical Research Center, Manchester University Hospitals National Health Service (NHS) Foundation Trust, Manchester, United Kingdom.
Sarah E DiverDepartment of Respiratory Sciences, Institute for Lung Health and Leicester NIHR Biomedical Research Center, University of Leicester, Leicester, United Kingdom.ORCID 0000-0002-5803-5121
Peter HowarthSchool of Clinical and Experimental Sciences, University of Southampton, National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Center, Southampton, United Kingdom.
James Lordanthe Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Andrew Menzies-GowDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, the University of Manchester, Royal Brompton and Harefield Hospitals, London, United Kingdom.ORCID 0000-0001-9707-4986
Timothy HarrisonNottingham Respiratory NIHR Biomedical Research Center, University of Nottingham, Nottingham, United Kingdom.
Douglas S RobinsonUniversity College Hospitals NHS Foundation Trust, London, United Kingdom.
Cecile T J HolwegGenentech Inc., San Francisco, California.
John G Matthews23andMe, Sunnyvale, California; and.
Ian D PavordOxford Respiratory NIHR Biomedical Research Center, Nuffield Department of Medicine, the University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4288-5973
Liam G HeaneyCenter for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom.ORCID 0000-0002-9176-5564
Funding
Medical Research Council MR/M016579/1
Abstract
PubMed holds no abstract for this paper.
Indexed as
Anti-Asthmatic AgentsAsthmaAdrenal Cortex HormonesBiomarkersDisease ProgressionFemaleHumansMalePhenotypeRisk FactorsAdrenal Cortex HormonesAnti-Asthmatic AgentsBiomarkersexacerbationsevere asthmaT2-low
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.