Evidence map›Paper›PMID 35549715›Full record

ArticleJournal of nanobiotechnology2022

Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects.

Kai Wu, Ali Mohsin, Waqas Qamar Zaman, Zefei Zhang, Wenyan Guan, Maoquan Chu, Yingping Zhuang, Meijin Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  5. [Application of drug delivery microspheres in cancer therapy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Kai Wu *State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O. Box 329#, Shanghai, 200237, People's Republic of China.
Ali Mohsin *State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O. Box 329#, Shanghai, 200237, People's Republic of China.
Waqas Qamar ZamanInstitute of Environmental Sciences and Engineering, School of Civil and Environmental Engineering, National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan.
Zefei ZhangBiomedical Multidisciplinary Innovation Research Institute and Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, People's Republic of China.
Wenyan GuanMaterials and Biomaterials Science and Engineering, University of California, Merced, CA, 95343, USA.
Maoquan ChuBiomedical Multidisciplinary Innovation Research Institute and Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, People's Republic of China. mqchu98@tongji.edu.cn.
Yingping ZhuangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O. Box 329#, Shanghai, 200237, People's Republic of China.
Meijin GuoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, P.O. Box 329#, Shanghai, 200237, People's Republic of China. guo_mj@ecust.edu.cn.ORCID http://orcid.org/0000-0002-3171-4802
East China University of Science and Technology · CNNational University of Sciences and Technology · PKShanghai East Hospital · CNTongji University · CNUniversity of California, Merced · US

Funding

Fundamental Research Funds for the Central Universities No.22221817014Fundamental Research Funds for the Central Universities No.22221818014National Key Research and Development Program of China 2018YFA0900300Open Funding Project of State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology 2019
6 · The paper itself

Abstract

backgroundMagnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth.

resultsIn this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe

conclusionsThe biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects.

Indexed as

NeoplasmsPhotochemotherapyAnimalsCell Line, TumorCell SurvivalMagnetic PhenomenaMicrospheresPhotosensitizing AgentsPhotosensitizing AgentsLaryngocarcinoma therapyMagneto-mechanic forcePhotodynamic effectPhotothermal effectUrchin-like hollow magnetic microspheres

Identifiers

PMID35549715
PMCPMC9097396
OpenAlexW4280602151

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.