ArticleBMC endocrine disorders2022
Serum liver enzymes and diabetes from the Rafsanjan cohort study.
Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 47 citations in OpenAlex.
- Association of the fibrosis-4 index with prevalent diabetes among adults: a cross-sectional analysis of NHANES 2003-2018 and a Chinese hospital-based health examination population.Frontiers in endocrinology · 2026Article
- Lipid Parameters and Their Association With Liver Function Test Variables in Patients With Type 2 Diabetes Mellitus.Cureus · 2025Article
- Association Between Uric Acid to HDL-C Ratio and Liver Transaminase Abnormalities: Insights from a Large-Scale General Population Study.Medicina (Kaunas, Lithuania) · 2025Article
- Association of hepatic biomarkers with incident diabetes: a mediation analysis of the triglyceride-glucose index in a large Chinese cohort.Lipids in health and disease · 2025Article
- Kidney stone and risk of cardiovascular diseases: a cross-sectional study in the southeast of Iran.BMC nephrology · 2025Article
- Risk factor assessment of prediabetes and diabetes based on epidemic characteristics in new urban areas: a retrospective and a machine learning study.Scientific reports · 2025Article
- Anthropometric Indices and Diabetes Disease: Based on the Rafsanjan Cohort Study.International journal of preventive medicine · 2025Article
- Elevated liver enzymes and diabetes in the PERSIAN Guilan cohort study.Caspian journal of internal medicine · 2025Article
- An Exploration of Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) Platelet Ratio Index (APRI) Scores with Dysglycemia and Diabetic Retinopathy: The Beichen Eye Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Umbilical Cord-Derived Mesenchymal Stem Cells Infusion in Type 2 Diabetes Mellitus Patients: A Retrospective Cytopeutics' Registry Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The Anti-Diabetic Effect of Non-Starch Polysaccharides Extracted from Wheat Beer on Diet/STZ-Induced Diabetic Mice.Foods (Basel, Switzerland) · 2024Article
- The association of ALT to HDL-C ratio with type 2 diabetes in 50-74 years old adults: a population-based study.Scientific reports · 2024Article
- Serum Gamma Glutamyl Transferase: Understanding its Contribution as a Potential Predictor of the Occurrence of Type 2 Diabetes.Current diabetes reviews · 2024Review
- Clinical Evidence of the Relationship Between Alanine Aminotransferase and Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association between liver enzymes and type 2 diabetes: a real-world study.Frontiers in endocrinology · 2024Article
- Investigating the relationship between liver enzymes and incidence of hypertension: A population-based cohort study in Kharameh, a city in the South of Iran.Health science reports · 2023Article
- AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study.Life (Basel, Switzerland) · 2023Article
- Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross-sectional study of Iranian adults, 2018-2022.Journal of clinical laboratory analysis · 2023Article
- Dietary antioxidants and liver enzymes in Rafsanjan, a Region in Southeast Iran.Scientific reports · 2023Article
- Elevated Circulating Fibroblast Growth Factor 21 in Lean Type 2 Diabetes: Evidence of Metabolic Dysregulation in the Absence of Adiposity.Kansas journal of medicineArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated the relation between ALT, AST, GGT and ALP with diabetes in the Rafsanjan Cohort Study. MATERIALS AND
methodsThe present study is a cross-sectional research including 9991 adults participated via sampling. We used data obtained from the Rafsanjan Cohort Study (RCS), as a part of the prospective epidemiological research studies in IrAN (PERSIAN). Elevated serum levels of ALT, AST, GGT and ALP were defined according to the reference range of the laboratory in the cohort center. Serum liver enzymes levels within the normal range were categorized into quartiles, and their relationship with diabetes was evaluated by logistic regressions.
findingsIn present study, elevated serum levels of ALT, AST, GGT, and ALP were associated with increased odds of diabetes (adjusted ORs: 1.81, 95%CI 1.51-2.17; 1.75, 95%CI 1.32-2.32; 1.77, 95%CI 1.50-2.08; 1.60, 95%CI 1.35-1.90 respectively). Also, in subjects with normal levels of ALT, GGT and ALP, a dose-response increase was shown for diabetes.
conclusionElevated levels of ALT, AST, GGT and ALP are related to a higher odds of diabetes. Also, increased levels of ALT, GGT and ALP even within normal range were independently related with the increased odds of diabetes. These results indicated the potential of elevated liver enzymes as biomarkers for the possible presence of diabetes.
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