Observational studyAmerican journal of respiratory and critical care medicine2022
Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study.
Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph
Observational study in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Incidence and Risk Factors for Progression from Pre-COPD to COPD: A Systematic Review and Meta‑analysis.International journal of chronic obstructive pulmonary disease · 2026Pooled it
- GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD.The European respiratory journal · 2025Guideline
- New spirometry recommendations from the Brazilian Thoracic Association - 2024 update.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
- Borderline Forced Expiratory Volume in 1 Second to Forced Vital Capacity and Low Forced Expiratory Volume in 1 Second Predict Disease Progression in High-Risk Populations With COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Clinical characteristics, symptom burden, and pulmonary function trajectories of spirometry- and MMEF-defined bronchodilator responsiveness in COPD: a single-center prospective study.Journal of thoracic disease · 2026Article
- Review
- Mapping the trajectory from pre-COPD to COPD: predictive value of symptoms, imaging, and physiologic abnormalities.Annals of the American Thoracic Society · 2026Article
- Pre-COPD: Impact on prevention, detection, and treatment.Presse medicale (Paris, France : 1983) · 2026Review
- Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.Nature genetics · 2026Article
- Longitudinal Outcomes and Prognostic Risk of Normalized Airflow Obstruction in a Korean General Population Cohort.International journal of chronic obstructive pulmonary disease · 2026Article
- Evaluation of Clinical Characteristics and Lung Function Trajectories in Young COPD Patients Within the General Population.International journal of chronic obstructive pulmonary disease · 2026Article
- Prognostic impact of pre- and post-bronchodilator airflow obstruction and post-bronchodilator reference values in a population-based study. On behalf of the PLATINO group.Respiratory research & clinical practice · 2026Article
- Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts.ERJ open research · 2025Article
- Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- Challenges and the Future of Pulmonary Function Testing in Chronic Obstructive Pulmonary Disease (COPD): Toward Earlier Diagnosis of COPD.Tuberculosis and respiratory diseases · 2025Article
- Heterogeneity of reduced FEVRespirology (Carlton, Vic.) · 2025Article
- Lung Volumes in Smokers without Chronic Obstructive Pulmonary Disease: A Pointer to Disease Development?Annals of the American Thoracic Society · 2025Article
- Unlocking the link: predicting cardiovascular disease risk with a focus on airflow obstruction using machine learning.BMC medical informatics and decision making · 2025Article
- Longitudinal analysis of adiponectin to leptin and apolipoprotein B to A1 ratios as markers of future airflow obstruction and lung function decline.Scientific reports · 2024Observational
- Association between measures of kidney function and preserved ratio impaired spirometry in diabetes: NHANES 2007-2012.BMJ open · 2024Article
Corrections and comments
- Commented on by
Authors and funding
20 authors at 13 institutions in 1 country.
Russell G BuhrDivision of Pulmonary and Critical Care Medicine, and.ORCID 0000-0001-6159-7435
Igor Z BarjaktarevicDivision of Pulmonary and Critical Care Medicine, and.ORCID 0000-0002-8096-0858
P Miguel QuibreraCollaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
Lori A BatemanCollaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
Eugene R BleeckerDivision of Genetics, Genomics, and Precision Medicine, University of Arizona, Tucson, Arizona.ORCID 0000-0002-4767-3494
David J CouperCollaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.ORCID 0000-0002-4313-9235
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.ORCID 0000-0001-5191-4847
Brett A DolezalDivision of Pulmonary and Critical Care Medicine, and.ORCID 0000-0003-0405-608X
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.ORCID 0000-0002-9095-4419
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8740-9751
Jerry A KrishnanBreathe Chicago Center, Division of Pulmonary and Critical Care Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois.ORCID 0000-0001-5525-4778
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0002-2412-3182
William McKleroyDivision of Pulmonary and Critical Care Medicine, University of California, San Francisco, California.ORCID 0000-0002-3184-9256
Robert PaineDivision of Respiratory, Critical Care, and Occupational Medicine, University of Utah School of Medicine, Salt Lake City, Utah.ORCID 0000-0002-4511-4437
Stephen I RennardDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0001-7909-0253
Donald P TashkinDivision of Pulmonary and Critical Care Medicine, and.ORCID 0000-0002-5607-4872
Prescott G WoodruffDivision of Pulmonary and Critical Care Medicine, University of California, San Francisco, California.ORCID 0000-0003-3176-0603
Richard E KannerDivision of Respiratory, Critical Care, and Occupational Medicine, University of Utah School of Medicine, Salt Lake City, Utah.ORCID 0000-0001-6915-599X
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, and.ORCID 0000-0002-6314-0903
SPIROMICS Investigators
Pulmonary and Critical Care Associates · USUniversity of North Carolina at Chapel Hill · USUniversity of California, San Francisco · USUniversity of Utah · USColumbia University · USHealth Services Research & Development · USJohns Hopkins University · USMichigan Medicine · USUniversity of Arizona · USUniversity of California, Los Angeles · USUniversity of Illinois Chicago · USUniversity of Nebraska Medical Center · USVA Ann Arbor Healthcare System · US
Funding
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MThe Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MPrediction of COPD Progression by PRMR01HL150023 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALBAN, CRAIG J, HAN, MEILAN K · 2020 to 2023
$2.8MDefining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MNCATS NIH HHS KL2 TR001882NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K24 HL137013NHLBI NIH HHS K24 HL138188NHLBI NIH HHS L30 HL134025NHLBI NIH HHS R01 HL150023NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK054759
Abstract
PubMed holds no abstract for this paper.
Indexed as
Airway ObstructionAsthmaPulmonary Disease, Chronic ObstructiveBronchodilator AgentsCohort StudiesForced Expiratory VolumeHumansSpirometryVital CapacityBronchodilator AgentsCOPDmultilevel modelingpulmonary physiologyspirometrysurvival analysis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.