Evidence map›Paper›PMID 35549411›Full record

ArticleScience (New York, N.Y.)2022

Noninvasive assessment of gut function using transcriptional recording sentinel cells.

Florian Schmidt, Jakob Zimmermann, Tanmay Tanna, Rick Farouni, Tyrrell Conway, Andrew J Macpherson, Randall J Platt

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 89 citations in OpenAlex.

  1. Trial
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  8. Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026
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  19. The lives of cells, recorded.Nature reviews. Genetics · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Florian Schmidt *Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.ORCID 0000-0002-6362-211X
Jakob Zimmermann *Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.ORCID 0000-0002-6302-6844
Tanmay Tanna *Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.ORCID 0000-0002-1150-0188
Rick FarouniDepartment of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.ORCID 0000-0002-3454-2946
Tyrrell ConwayDepartment of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-0938-4149
Andrew J MacphersonDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.ORCID 0000-0002-7192-0184
Randall J PlattDepartment of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.ORCID 0000-0002-2914-7052
ETH Zurich · CHUniversity of Bern · CHOklahoma State University · USUniversity of Basel · CH

Funding

Mechanisms of Nutrient Competition in the IntestineR01GM117324 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CONWAY, TYRRELL · 2017 to 2020
$1.4M
NIGMS NIH HHS R01 GM117324
6 · The paper itself

Abstract

Transcriptional recording by CRISPR spacer acquisition from RNA endows engineered

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsEscherichia coliGastrointestinal MicrobiomeGastrointestinal TractHost Microbial InteractionsAnimalsMiceTranscriptome

Identifiers

PMID35549411
PMCPMC11163514
OpenAlexW4280534378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.