Evidence map›Paper›PMID 35548925›Full record

ArticleArtificial organs2022

The role of hypothermic machine perfusion in selecting renal grafts with advanced histological score.

Franco Ruberto, Quirino Lai, Mario Piazzolla, Matteo Brisciani, Renzo Pretagostini, Manuela Garofalo, Francesco Giovanardi, Francesco Nudo, Luca Poli, Veronica Zullino and 4 more

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In one paragraph

Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Franco RubertoDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0001-7282-9457
Quirino LaiGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-1487-3235
Mario PiazzollaDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Matteo BriscianiDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Renzo PretagostiniGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Manuela GarofaloGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Francesco GiovanardiGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Francesco NudoGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Luca PoliGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Veronica ZullinoDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Pietro SantopietroDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Massimo RossiGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Pasquale B BerlocoGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Francesco PuglieseDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies explored the role of hypothermic machine perfusion (HMP) in the sub-group of non-standard renal grafts with a biopsy-proven advanced histological impairment. This study aimed to investigate the role of HMP in grafts with a Karpinski Score >3 in terms of the need for dialysis, creatinine reduction ratio at day-7 (CRR7), and 3-year graft survival.

methodsTwenty-three perfused grafts with Karpinski Score >3 evaluated between November 2017 and December 2018 were retrospectively analyzed and compared with a control group of 32 non-perfused grafts transplanted between January 2014 and October 2017.

resultsAfter transplantation, perfused grafts had fewer cases requiring dialysis (8.7% vs. 34.4%; p = 0.051), a better reduction in serum creatinine (median at 7 days: 2.2 vs. 4.3 mg/dl; p = 0.045), and shorter length of hospital stay (median 11 vs. 15 days; p = 0.01). Three-year death-censored graft survival was better in the perfused cases (91.3% vs. 77.0%; p = 0.16). In perfused grafts, initial renal resistance (RR) had the best predictive value for renal function recovery after the first week, as defined by CRR7 ≤ 70% (AUC = 0.83; p = 0.02). A cut-off value of 0.5 mm Hg/ml/min showed a sensitivity of 82.4%, a specificity of 83.3%, and diagnostic odds ratio = 23.4. After dividing the entire population into a Low-RR (n = 8) and a High-RR Group (n = 15), more cases with CRR7 ≤ 70% were reported in the latter group (86.7 vs. 13.3%; p = 0.03).

conclusionHMP yielded promising results in kidneys with Karpinski Score >3. Initial RR should be of interest in selecting non-standard organs for single kidney transplantation even in impaired histology.

Indexed as

Kidney TransplantationDelayed Graft FunctionGraft SurvivalHumansKidneyOrgan PreservationPerfusionRetrospective StudiesTissue Donorsdelayed graft functiondialysisgraft lossKarpinski Scoreperfusionserum creatinine

Identifiers

PMID35548925
PMCPMC9544822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.