ArticleArtificial organs2022
A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results.
Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Presentation of preload and afterload to isolated heart preparations.The Journal of physiology · 2026Review
- Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment.Journal of visualized experiments : JoVE · 2024Article
- Ex Vivo Working Porcine Heart Model.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results.Artificial organs · 2022Article
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Authors and funding
6 authors.
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Abstract
backgroundExisting working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed to enable such control.
methodsSix ∼70 kg pig hearts were evaluated in vivo, then ex vivo in left-ventricular working mode using the presented afterload. Both in vivo and ex vivo, the hearts were evaluated at two exertion levels: at rest and following a 20 μg adrenaline bolus, while measuring aortic pressure and flow, left ventricular pressure and volume, and left atrial pressure.
resultsThe afterload gave aortic pressure waveforms that matched the general shape of the in vivo measurements. A wide range of physiological systolic pressures (93 to 160 mm Hg) and diastolic pressures (73 to 113 mm Hg) were generated by the afterload.
conclusionsWith the presented afterload concept, multiple physiological loading conditions could be tested ex vivo, and compared with the corresponding in vivo data. An additional control loop from the set pressure limits to the measured systolic and diastolic aortic pressure is proposed to address discrepancies observed between the set limits and the measured pressures.
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