ReviewActa physiologica (Oxford, England)2022
New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.
Review in Acta physiologica (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Mitochondrial responses to anoxia-reoxygenation exposure in crucian carp (Carassius carassius).The Journal of experimental biology · 2026Article
- Association of Hemoglobin and Myoglobin into Supramolecular Complexes: Significance for Life and Practice.International journal of molecular sciences · 2025Review
- Adaptations to hypoxia in the vertebrate retina.The Journal of physiology · 2025Review
- Ecometabolomics reveal physiological adaptations of Asiatic toads (Bufo gargarizans Cantor, 1842) to different environments along an altitudinal gradient.Frontiers in zoology · 2025Article
- Neural Processing without OPhysiology (Bethesda, Md.) · 2024Review
- Maintained mitochondrial integrity without oxygen in the anoxia-tolerant crucian carp.The Journal of experimental biology · 2024Article
- Article
- Metabolomic Profiling Reveals Differences in Hypoxia Response between Far Eastern and Siberian Frogs.Animals : an open access journal from MDPI · 2023Article
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Characterization of Carnosine Effect on Human Microglial Cells under Basal Conditions.Biomedicines · 2023Article
- Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (PeerJ · 2023Article
- New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.Acta physiologica (Oxford, England) · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxic environments pose a severe challenge to vertebrates and even short periods of oxygen deprivation are often lethal as they constrain aerobic ATP production. However, a few ectotherm vertebrates are capable of surviving long-term hypoxia or even anoxia with little or no damage. Among these, freshwater turtles and crucian carp are the recognized champions of anoxia tolerance, capable of overwintering in complete oxygen deprivation for months at freezing temperatures by entering a stable hypometabolic state. While all steps of the oxygen cascade are adjusted in response to oxygen deprivation, this review draws from knowledge of freshwater turtles and crucian carp to highlight mechanisms regulating two of these steps, namely oxygen transport in the blood and oxygen utilization in mitochondria during three sequential phases: before anoxia, when hypoxia develops, during anoxia, and after anoxia at reoxygenation. In cold hypoxia, reduced red blood cell concentration of ATP plays a crucial role in increasing blood oxygen affinity and/or reducing oxygen unloading to tissues, to adjust aerobic metabolism to decrease ambient oxygen. In anoxia, metabolic rewiring of oxygen utilization keeps largely unaltered NADH/NAD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.