Evidence map›Paper›PMID 35548881›Full record

ArticleBiomolecules & therapeutics2022

Abiraterone Acetate Attenuates SARS-CoV-2 Replication by Interfering with the Structural Nucleocapsid Protein.

Jinsoo Kim, Seok Young Hwang, Dongbum Kim, Minyoung Kim, Kyeongbin Baek, Mijeong Kang, Seungchan An, Junpyo Gong, Sangkyu Park, Mahmoud Kandeel and 3 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Biomolecules & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Jinsoo KimDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Seok Young HwangCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Dongbum KimInstitute of Medical Science, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Minyoung KimDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Kyeongbin BaekDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Mijeong KangDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Seungchan AnCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Junpyo GongCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Sangkyu ParkDepartment of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea.
Mahmoud KandeelDepartment of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf 31982, Saudi Arabia.
Younghee LeeDepartment of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea.
Minsoo NohCollege of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Hyung-Joo KwonDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea.
Hallym University · KRSeoul National University · KRChungbuk National University · KRKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The drug repurposing strategy has been applied to the development of emergency COVID-19 therapeutic medicines. Current drug repurposing approaches have been directed against RNA polymerases and viral proteases. Recently, we found that the inhibition of the interaction between the SARS-CoV-2 structural nucleocapsid (N) and spike (S) proteins decreased viral replication. In this study, drug repurposing candidates were screened by

Indexed as

Abiraterone acetateDocking simulationDrug repurposingNucleocapsid proteinSARS-CoV-2Virtual screening

Identifiers

PMID35548881
PMCPMC9424333
OpenAlexW4280532275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.