ReviewRSC advances2018
Scope and advances in the catalytic propargylic substitution reaction.
Review in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 136 citations in OpenAlex.
- Enantioselectivity in Transition Metal Catalyzed Propargylic Substitution Reactions: A Theoretical Perspective.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Outcompeting hydrofunctionalization: Asymmetric remote substitution of alkynes.Science advances · 2025Article
- De-Saturation of Single-Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- A Base-Mediated Rearrangement of the Benzylic 1,5-Hexadipyridynyl Moiety.ChemPlusChem · 2025Article
- Enantioselective construction of cyclic quaternary stereocenters via dinuclear copper catalyzed asymmetric [3 + 2] propargylation/annulation.Nature communications · 2025Article
- An Organometallic Umpolung Approach for Iron-Mediated Propargylic C-H Etherification.Angewandte Chemie (International ed. in English) · 2024Article
- Copper-catalyzed yne-allylic substitutions: concept and recent developments.Beilstein journal of organic chemistry · 2024Review
- Cationic indium catalysis as a powerful tool for generating α-alkyl propargyl cations for SCommunications chemistry · 2023Article
- Article
- Copper-catalyzed propargylic C-H functionalization for allene syntheses.Chemical science · 2023Article
- Synthesis of Blue Emissive Quaternary 9,9-DisubstitutedACS omega · 2023Article
- Unexpected Decarbonylation of Acylethynylpyrroles under the Action of Cyanomethyl Carbanion: A Robust Access to Ethynylpyrroles.Molecules (Basel, Switzerland) · 2023Article
- Article
- Stereoselective synthesis of C3-tetrasubstituted oxindolesRSC advances · 2022Article
- Practical asymmetric amine nucleophilic approach for the modular construction of protected α-quaternary amino acids.Chemical science · 2022Article
- Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation.Nature communications · 2021Article
- Rice husk-SiORSC advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleophilic displacement of the propargylic alcohol is one of the sought-after methods in the current scenario. The highly nucleophilic alkyne functional moiety along with its considerably acidic terminal hydrogen atom allows the propargylic unit to play a crucial role in organic synthesis by offering a handle for further synthetic transformations. Until 2000, the most fundamental propargylic substitution reaction was the Nicolas reaction, a multi-step transformation, developed in 1972, which involved cobalt as a stoichiometric promoter. Therefore, the direct catalytic substitution of propargylic alcohols was a highly desirable method for development. The pioneering work on the Ru-catalyzed propargylic substitution reaction in 2000 encouraged many researchers to develop several novel catalytic propargylic substitution reactions, which have made rapid progress since then. The purpose of this review is to emphasise the involvement of diverse types of Lewis acid, transition metal and Brønsted acid catalysts in the propargylic substitution reaction and provide an updated summary of the recent developments in this field. The selected examples presented here are the most significant and relevant ones and we believe that this will help the readers to comprehend the scope of the propargylic substitution reaction with diverse types of catalysts and will envisage the scientific community for the future developments in this field.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.