Evidence map›Paper›PMID 35548683›Full record

ReviewFrontiers in toxicology2022

Probing the Neural Circuitry Targets of Neurotoxicants

Marcia H Ratner, David H Farb

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marcia H RatnerDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
David H FarbDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
Boston University · US

Funding

PRE- AND POSTDOCTORAL TRAINING IN BIOCHEMISTRY OF AGINGT32AG000115 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI POLGAR, PETER RUDOLPH · 1985 to 2012
$4.3M
Age-Related Changes in Neural Network Activity and Tau in a rat model of Alzheimer's DiseaseR21AG056947 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 2018 to 2019
$454k
NIA NIH HHS R21 AG056947NIA NIH HHS T32 AG000115
6 · The paper itself

Abstract

Adverse effects of drugs on the human nervous system are rarely possible to anticipate based on preclinical neurotoxicity data, thus propagating the centuries long single most important obstacle to drug discovery and development for disorders of the nervous system. An emerging body of evidence indicates that

Indexed as

behavioral testingin vivo electrophysiologylocal field potential (LFP)neural networkplace cell recordings

Identifiers

PMID35548683
PMCPMC9081674
OpenAlexW4224324307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.