Evidence map›Paper›PMID 35548612›Full record

ArticleRSC advances2018

Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells.

Lei Zhang, Ying Rong, Jie Zheng, Chengli Yang, Yongzheng Chen, Jing Wang, Gang Wei

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Lei ZhangGeneric Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University Zunyi 563003 PR China lzhang@zmc.edu.cn wangjing@zmc.edu.cn.ORCID https://orcid.org/0000-0002-6968-0492
Ying RongSecond Department of Pediatrics, Affiliated Hospital of Zunyi Medical University Zunyi 563003 PR China.
Jie ZhengDepartment of Nephrology & Rheumatology, Affiliated Hospital of Zunyi Medical University Zunyi 563003 PR China.
Chengli YangGeneric Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University Zunyi 563003 PR China lzhang@zmc.edu.cn wangjing@zmc.edu.cn.
Yongzheng ChenGeneric Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University Zunyi 563003 PR China lzhang@zmc.edu.cn wangjing@zmc.edu.cn.
Jing WangGeneric Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University Zunyi 563003 PR China lzhang@zmc.edu.cn wangjing@zmc.edu.cn.ORCID https://orcid.org/0000-0002-9927-6714
Gang WeiCSIRO Manufacturing PO Box 218, Lindfield NSW 2070 Australia gang.wei@csiro.au.
Zunyi Medical University · CNCSIRO Manufacturing · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistance remains a major obstacle for the effective treatment of carcinoma. To find new drugs for the chemotherapy of drug-resistant leukemia, in this study, two novel nitric oxide-donating podophyllotoxin derivatives were synthesized and preliminarily evaluated

Identifiers

PMID35548612
PMCPMC9087117
OpenAlexW2895314402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.