Evidence map›Paper›PMID 35548571›Full record

ArticleFrontiers in nutrition2022

DIet and Health From reGIstered Trials on ClinicalTrials.gov: The DIGIT Study.

Monica Dinu, Giuditta Pagliai, Cristian Del Bo', Marisa Porrini, Patrizia Riso, Mauro Serafini, Francesco Sofi, Daniela Martini, Donato Angelino

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monica DinuDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giuditta PagliaiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Cristian Del Bo'Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Marisa PorriniDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Patrizia RisoDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Mauro SerafiniFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Francesco SofiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Daniela MartiniDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Donato AngelinoFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clinical trial registration has become a valuable tool that can be used to track the status and nature of trials conducted on a specific topic. This approach has been applied to many areas of research, but less is known about the characteristics and trends over time of clinical trials focused on diet and health. The aim of this study was to analyze diet-related clinical trials registered on the National Institute of Health "ClinicalTrials.gov" web platform in the last 10 years, to list and describe their characteristics, and to identify possible gaps to be filled in the future research. Methods: A search was performed on the ClinicalTrials.gov database. Intervention studies registered from January 2010 to December 2020, conducted on adults, with a follow-up of ≥2 weeks, evaluating the impact of different diets on all outcomes except those assessed with scales or questionnaires were considered. Results: At the end of the selection process, a total of 1,016 registered clinical trials were identified and included in the analysis. The most investigated dietary approaches were balanced diets ( Conclusion: The number of studies investigating the relationship between diet and health has increased over the years. Despite the growing interest in the topic, there are some gaps, such as the limited duration of most trials, the underrepresentation of some population groups, and the limited number of studies for some diets that, although popular in the population, lack robust scientific evidence.

Indexed as

clinical trialsdietdietary intervention studydietary patternfood timinghumanslow-carb dietsMediterranean diet

Identifiers

PMID35548571
PMCPMC9083457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.