ArticleRSC advances2019
Hybrid cellulose nanocrystal/alginate/gelatin scaffold with improved mechanical properties and guided wound healing.
Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Recent Advances in Smart Wound Healing Patches: From Passive Dressings to Intelligent Theranostic Systems.Cureus · 2026Review
- Plant-Based Scaffolds in Tissue Engineering: Structure-Function, Processing, and Clinical Outlook-A Review.Annals of biomedical engineering · 2026Review
- Design and Performance of a Novel Scalable Core-Sheath Inverted Nozzle Soft Material Pressure Spinner.ACS polymers Au · 2026Article
- Growth Hormone-Loaded 3D Printed Silk Fibroin-Cellulose Dressings for Ischemic Wounds.Advanced healthcare materials · 2026Article
- Article
- Sprayable Cellulose and Mannan Nanocrystals from Ivory Nuts for Treatment of Skin Diseases in Mice.ACS applied bio materials · 2025Article
- Bilayer Biomimetic Scaffolds Loaded with Mesenchymal Stem Cell Secretomes Promote Diabetic Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Wound Healing: Molecular Mechanisms, Antimicrobial Peptides, and Emerging Technologies in Regenerative Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Effects of Carbon-Based and Organic Nanoparticles in Advanced Dressings for Skin Regeneration: A Review.International wound journal · 2025Review
- Chemical Modification of Nanocrystalline Cellulose for Manufacturing of Osteoconductive Composite Materials.Polymers · 2024Article
- Scaffold-Mediated Drug Delivery for Enhanced Wound Healing: A Review.AAPS PharmSciTech · 2024Review
- Efficacy of borneol-gypsum in skin regeneration and pain control in toxic epidermal necrolysis: A case report.World journal of clinical cases · 2024Article
- Urethral Microenvironment Adapted Sodium Alginate/Gelatin/Reduced Graphene Oxide Biomimetic Patch Improves Scarless Urethral Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Alginate-Gelatin Hydrogel Scaffolds; An Optimization of Post-Printing Treatment for Enhanced Degradation and Swelling Behavior.Gels (Basel, Switzerland) · 2023Article
- Adipose-Derived Stromal Cells within a Gelatin Matrix Acquire Enhanced Regenerative and Angiogenic Properties: A Pre-Clinical Study for Application to Chronic Wounds.Biomedicines · 2023Article
- Alginate-Based Hydrogels and Scaffolds for Biomedical Applications.Marine drugs · 2023Review
- The Fabrication of Gelatin-Elastin-Nanocellulose Composite Bioscaffold as a Potential Acellular Skin Substitute.Polymers · 2023Article
- The Role of Calcium in Wound Healing.International journal of molecular sciences · 2021Review
- A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting.Materials (Basel, Switzerland) · 2021Review
- Changes of Mineralogical Properties and Biological Activities of Gypsum and Its Calcined Products with Different Phase Structures.Evidence-based complementary and alternative medicine : eCAM · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature derived biopolymers such as polysaccharides and collagen have attracted considerable attention in biomedical applications. Despite excellent biocompatibility and bioactivity, their poor mechanical properties could not meet the requirement for skin regeneration. In this study, cellulose nanocrystal (CNC) was incorporated into the calcium cross-linked sodium alginate/gelatin (SA/Ge) scaffold to reinforce its physicochemical properties. A novel sodium alginate/gelatin/cellulose nanocrystal (SA/Ge/CNC) scaffold was successfully prepared through electrostatic interaction of sodium alginate and gelatin, ionic cross-linking of calcium ions with sodium alginate, and incorporation of CNC. Afterwards, the SA/Ge and SA/Ge/CNC scaffolds were fully characterized and compared with scanning electron microscopy images, swelling behaviors, tensile strengths and contact angles. The involvement of CNC produces a hybrid SA/Ge/CNC scaffold with desired porous network, moderate swelling behavior, and superior mechanical strength (from 18 MPa to 45 MPa). Furthermore,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.