Evidence map›Paper›PMID 35548247›Full record

ArticleRSC advances2018

Targeting HMGA protein inhibits retinoblastoma cell proliferation.

Akilandeswari Balachandran, Ajit Zambre, Jagjot Singh Kainth, Lakshmi Dhevi Nagarajha Selvan, Sowmya Parameswaran, Zahra Afrasiabi, Subramanian Krishnakumar, Raghuraman Kannan, Anandhi Upendran

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Akilandeswari BalachandranDepartment of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India drkk@snmail.org drkrishnakumar_2000@yahoo.com.
Ajit ZambreDepartment of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.
Jagjot Singh KainthDepartment of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.ORCID https://orcid.org/0000-0001-8521-2042
Lakshmi Dhevi Nagarajha SelvanL&T Ocular Pathology Department, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
Sowmya ParameswaranRadheshyam Kanoi Stem Cell Laboratory, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India.
Zahra AfrasiabiDepartment of Life Sciences, Lincoln University Jefferson City MO USA.
Subramanian KrishnakumarDepartment of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology Chennai India drkk@snmail.org drkrishnakumar_2000@yahoo.com.
Raghuraman KannanDepartment of Radiology, University of Missouri Columbia MO USA kannanr@health.missouri.edu.ORCID https://orcid.org/0000-0003-1980-3797
Anandhi UpendranDepartment of Medical Pharmacology and Physiology, University of Missouri Columbia MO USA.
Oil and Natural Gas Corporation (India) · INUniversity of Missouri · USLincoln University - Missouri · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

Identifiers

PMID35548247
PMCPMC9085636
OpenAlexW2890717057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.