Evidence map›Paper›PMID 35547965›Full record

ArticleRSC advances2018

Screening of ferrocenyl-phosphines identifies a gold-coordinated derivative as a novel anticancer agent for hematological malignancies.

Navin Kumar Verma, Abdul Sadeer, Atish Kizhakeyil, Jia Hao Pang, Qi Yun Angela Chiu, Shan Wen Tay, Pankaj Kumar, Sumod A Pullarkat

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Navin Kumar VermaLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building 59 Nanyang Drive Singapore nkverma@ntu.edu.sg.ORCID https://orcid.org/0000-0002-5940-6633
Abdul SadeerDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University Singapore 21 Nanyang Link Singapore Sumod@ntu.edu.sg.
Atish KizhakeyilLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building 59 Nanyang Drive Singapore nkverma@ntu.edu.sg.
Jia Hao PangDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University Singapore 21 Nanyang Link Singapore Sumod@ntu.edu.sg.
Qi Yun Angela ChiuDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University Singapore 21 Nanyang Link Singapore Sumod@ntu.edu.sg.
Shan Wen TayDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University Singapore 21 Nanyang Link Singapore Sumod@ntu.edu.sg.
Pankaj KumarLee Kong Chian School of Medicine, Nanyang Technological University Singapore, Experimental Medicine Building 59 Nanyang Drive Singapore nkverma@ntu.edu.sg.
Sumod A PullarkatDivision of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University Singapore 21 Nanyang Link Singapore Sumod@ntu.edu.sg.ORCID https://orcid.org/0000-0002-4150-2408
Nanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of new organometallic compounds as anticancer agents is currently an active area of research. Here, we report the design, synthesis and characterization of a panel of 10 new ferrocenyl-phosphine derivatives (FD1-FD10) and the analysis of their anti-proliferative activities in hematolymphoid cells representing non-Hodgkin cutaneous T-cell lymphoma (CTCL). The gold-coordinated ferrocenyl-phosphine complex FD10 exhibited a significant and dose-dependent cytotoxicity in 4 different CTCL cell lines - HuT78, HH, MJ and MyLa. FD10 concentrations causing 50% cell growth inhibition (IC

Identifiers

PMID35547965
PMCPMC9084421
OpenAlexW2887534841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.