Evidence map›Paper›PMID 35547901›Full record

ArticleRSC advances2018

Synthesis, antitumor activity and molecular mechanism of doxorubicin conjugated trimethyl-chitosan polymeric micelle loading Beclin1 siRNA for drug-resisted bladder cancer therapy.

Zhou Zhong, Zhong Cheng, Dongyuan Su, Ting Xu, Xiang Li, Fengbo Wu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Zhou ZhongDepartment of Urology and Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu 610041 China xiangli.87@scu.edu.cn wfb_sc@163.com.
Zhong ChengDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University Chengdu 610041 China.
Dongyuan SuDepartment of Gastroenterology, Chongzhou People's Hospital Chengdu 611230 China.
Ting XuDepartment of Pharmacy, West China Hospital, Sichuan University Chengdu 610041 China.
Xiang LiDepartment of Urology and Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu 610041 China xiangli.87@scu.edu.cn wfb_sc@163.com.
Fengbo WuDepartment of Urology and Department of Orthopaedic Surgery, West China Hospital, Sichuan University Chengdu 610041 China xiangli.87@scu.edu.cn wfb_sc@163.com.ORCID https://orcid.org/0000-0003-0042-8456
Sichuan University · CNChengdu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we describe a convenient approach for the preparation of a polymeric micelle using doxorubicin (DOX) conjugated trimethyl-chitosan (TMC) with Beclin-1 siRNA (Si-Beclin1/DOX-TMC). This micelle displayed a potent capacity for autophagy inhibition and reversed drug-resistance to DOX in BIU-87/ADR cell lines. The Si-Beclin1/DOX-TMC micelle was highly cytotoxic to both drug-sensitive BIU-87 and drug-resistant BIU-87/ADR cells. Its capacity to reverse drug-resistance was dependent upon upregulation of autophagy levels in BIU-87/ADR cells. DOX was conjugated to TMC

Identifiers

PMID35547901
PMCPMC9087860
OpenAlexW2896777781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.