Evidence map›Paper›PMID 35547853›Full record

ArticleResearch square2022

Adaptive MHC-E restricted tissue-resident NK cells are associated with persistent low antigen load in alveolar macrophages after SARS-CoV-2 infection.

Nicolas Huot, Cyril Planchais, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Pierre Rosenbaum, Félix Rey, R Keith Reeves, Roger Le Grand and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nicolas Huotinstitut pasteur.ORCID 0000-0001-5982-7991
Cyril PlanchaisInstitut Pasteur.
Vanessa ContrerasCEA - Université Paris Saclay - INSERM U1184.
Beatrice Jacquelininstitut pasteur.ORCID 0000-0002-1896-5092
Caroline Petitdemangeinstitut pasteur.
Marie Lazzeriniinstitut pasteur.
Pierre Rosenbauminstitut pasteur.
Félix ReyInstitut Pasteur.ORCID 0000-0002-9953-7988
R Keith ReevesBeth Israel Deaconess Medical Center.ORCID 0000-0003-3157-2557
Roger Le GrandUniversité Paris-Saclay, INSERM, CEA.ORCID 0000-0002-4928-4484
Hugo MouquetInstitut Pasteur.
Michaela Müller-TrutwinInstitut Pasteur, HIV, Inflammation and Persistence Unit.
Institut Pasteur · FRInserm · FRHadassah Medical Center · IL

Funding

Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid FolliclesR01AI143457 · NIAID · DUKE UNIVERSITY · PI REEVES, ROGER KEITH · 2019 to 2023
$3.1M
NK cell mobilization as a pathogenic etiology of SARS-CoV-2 gastrointestinal diseaseR01DK130472 · NIDDK · DUKE UNIVERSITY · PI REEVES, ROGER KEITH · 2021 to 2023
$1.2M
NIAID NIH HHS R01 AI143457NIDDK NIH HHS R01 DK130472
6 · The paper itself

Abstract

Natural killer (NK) cells are innate lymphocytes with potent activity against a wide range of viruses. In SARS-CoV-2 infection, NK cell activity might be of particular importance within lung tissues. Here, we investigated whether NK cells with activity against Spike

Identifiers

PMID35547853
PMCPMC9094104
OpenAlexW4224577394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.