Evidence map›Paper›PMID 35547845›Full record

ArticlemedRxiv : the preprint server for health sciences2022

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of Diseases.

Chunyu Liu, Roby Joehanes, Jiantao Ma, Yuxuan Wang, Xianbang Sun, Amena Keshawarz, Meera Sooda, Tianxiao Huan, Shih-Jen Hwang, Helena Bui and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Chunyu LiuDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Roby JoehanesPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jiantao MaNutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Yuxuan WangDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Xianbang SunDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Amena KeshawarzPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Meera SoodaPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Tianxiao HuanUniversity of Massachusetts Medical School, Worcester, MA, USA.
Shih-Jen HwangPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Helena BuiPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Brandon TejadaPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Peter J MunsonPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Demirkale CumhurUniversity of Massachusetts Medical School, Worcester, MA, USA.
Nancy L Heard-CostaFramingham Heart Study, Framingham, MA, USA.
Achilleas N PitsillidesDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Gina M PelosoDepartment of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
Michael FeoloUniversity of Massachusetts Medical School, Worcester, MA, USA.
Nataliya SharopovaUniversity of Massachusetts Medical School, Worcester, MA, USA.
Ramachandran S VasanFramingham Heart Study, Framingham, MA, USA.
Daniel LevyFramingham Heart Study, Framingham, MA, USA.
National Institutes of Health · USBoston University · USUniversity of Massachusetts Chan Medical School · USTufts University · US

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Trans-omic Analysis of Alcohol Consumption and its Relation to Cardiovascular DiseaseR01AA028263 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU, MA, JIANTAO · 2021 to 2025
$2.6M
Dietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K22 HL135075NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NIAAA NIH HHS R01 AA028263
6 · The paper itself

Abstract

To create a scientific resource of expression quantitative trail loci (eQTL), we conducted a genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) of DNA and gene expression levels from RNA sequencing (RNA-seq) of whole blood in 2622 participants in Framingham Heart Study. We identified 6,778,286

Identifiers

PMID35547845
PMCPMC9094109
OpenAlexW4223901647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.