ReviewRSC advances2018
Naphthoquinones of the spinochrome class: occurrence, isolation, biosynthesis and biomedical applications.
Review in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Halochromic modulation of amorphous calcium carbonate crystallization driven by pH-responsive bioinspired pigments.Nature communications · 2026Article
- Cytotoxic Synurins A-C: Chlorinated Naphthoquinone Pigments from the Freshwater AlgaJournal of natural products · 2026Article
- Extraction and characterization of a novel glycosylated naphthazarin pigment from mangrove Aspergillus unguis AUMC15225.Scientific reports · 2026Article
- Article
- Sea Urchin Food Waste into Bioactives: Collagen and Polyhydroxynaphtoquinones fromMarine drugs · 2024Article
- Marine Natural Products Rescuing the Eye: A Narrative Review.Marine drugs · 2024Review
- Dimeric (Poly)Hydroxynaphthazarins, Metabolites of Echinoderms and Lichens: The History of the Synthesis and Structure Elucidation.Marine drugs · 2023Review
- Quinoid Pigments of Sea UrchinsMarine drugs · 2022Review
- Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments.Journal of the American Chemical Society · 2022Article
- Evidence for association of Vibrio echinoideorum with tissue necrosis on test of the green sea urchin Strongylocentrotus droebachiensis.Scientific reports · 2022Article
- Multi-target bioactivity of summer quinones production in the Persian Gulf burrowing black-type sea urchin.Heliyon · 2022Article
- Echinoderms Metabolites: Structure, Functions, and Biomedical Perspectives.Marine drugs · 2021Article
- Spinochrome Identification and Quantification in Pacific Sea Urchin Shells, Coelomic Fluid and Eggs Using HPLC-DAD-MS.Marine drugs · 2021Article
- Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-Activity Analysis of Substituted 5,8-Dihydroxy-1,4-Naphthoquinones and theirMarine drugs · 2020Article
- Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1.Marine drugs · 2020Article
- Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products.Molecules (Basel, Switzerland) · 2020Article
- PHNQ fromMarine drugs · 2020Article
- Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins.Scientific reports · 2020Article
- Pharmacokinetic Study of Bioactive Glycopeptide fromMarine drugs · 2019Article
- Free Radical-Scavenging Capacities, Phenolics and Capsaicinoids in Wild Piquin Chili (Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quinones are widespread in nature and have been found in plants, fungi and bacteria, as well as in members of the animal kingdom. More than forty closely related naphthoquinones have been found in echinoderms, mainly in sea urchins but occasionally in brittle stars, sea stars and starfish. This review aims to examine controversial issues on the chemistry, biosynthesis, functions, stability and application aspects of the spinochrome class, a prominent group of secondary metabolites found in sea urchins. The emphasis of this review is on the isolation and structure of these compounds, together with evaluation of their relevant biological activities, source organisms, the location of origin and methods used for isolation and identification. In addition, the studies of their biosynthesis and ecological function, stability and chemical synthesis have been highlighted. This review aims to establish a focus for future spinochrome research and its potential for benefiting human health and well-being.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.