Evidence map›Paper›PMID 35547659›Full record

ArticleAdvances in neurobiology2011

Actin and Diseases of the Nervous System.

Barbara W Bernstein, Michael T Maloney, James R Bamburg

Open access · greenAbstract read
In one paragraph

Article in Advances in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026
    Review
  2. ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
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  5. Review
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  9. Review
  10. Article
  11. Review
  12. The axonal cytoskeleton: from organization to function.Frontiers in molecular neuroscience · 2015
    Review
  13. Article
  14. Cytoskeletal pathologies of Alzheimer disease.Cell motility and the cytoskeleton · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Barbara W BernsteinDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Michael T MaloneyDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
James R BamburgDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Colorado State University · US

Funding

ADF/cofilin-actin rods in neurodegenerative diseasesR01NS040371 · NINDS · COLORADO STATE UNIVERSITY-FORT COLLINS · PI BAMBURG, JAMES R · 2002 to 2009
$2.3M
Training in Synaptic NeurobiologyT32NS043115 · NINDS · COLORADO STATE UNIVERSITY-FORT COLLINS · PI BAMBURG, JAMES R · 2002 to 2006
$1.2M
Retrograde Transport at the Crossroads of Cognitive Delcine and NeurodegenerationF32HD055745 · NICHD · STANFORD UNIVERSITY · PI MALONEY, MICHAEL T · 2007 to 2009
$142k
NICHD NIH HHS F32 HD055745NINDS NIH HHS R01 NS040371NINDS NIH HHS T32 NS043115
6 · The paper itself

Abstract

Abnormal regulation of the actin cytoskeleton results in several pathological conditions affecting primarily the nervous system. Those of genetic origin arise during development, but others manifest later in life. Actin regulation is also affected profoundly by environmental factors that can have sustained consequences for the nervous system. Those consequences follow from the fact that the actin cytoskeleton is essential for a multitude of cell biological functions ranging from neuronal migration in cortical development and dendritic spine formation to NMDA receptor activity in learning and alcoholism. Improper regulation of actin, causing aggregation, can contribute to the neurodegeneration of amyloidopathies, such as Down's syndrome and Alzheimer's disease. Much progress has been made in understanding the molecular basis of these diseases.

Indexed as

Actin-depolymerizing factorAlzheimerCofilinDown’s syndromeNeurodegenerationRod

Identifiers

PMID35547659
PMCPMC9088176
OpenAlexW125011730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.