ReviewFrontiers in physiology2022
It's About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Aerobic exercise for depression symptoms in adolescents: a systematic review and dose-response meta-analysis.BMC public health · 2026Pooled it
- The impact of high-intensity exercise on patients with depression: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Effectiveness of exercise intervention on children and adolescents with depression: a systematic review and meta-analysis of randomized controlled trial.Frontiers in psychiatry · 2025Pooled it
- Plasma and salivary measures of testosterone and cortisol levels in basketball players under various games / training conditions, and nutritional strategies: an updated systematic review.Frontiers in physiology · 2025Pooled it
- The role of the cerebellum in internet gaming disorder-A systematic review.Addiction biology · 2023Pooled it
- Effects of cognitively engaging physical activity on executive function, mental health, and physical fitness in school-age children: a cluster-randomized controlled trial.BMC psychology · 2026Trial
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
- Acute 3.5-minute light-intensity exercise enhances executive function and psychological mood in children.Scientific reports · 2025Article
- School-Based Physical Activity, Cognitive Performance and Circadian Rhythms: Rethinking the Timing of Movement in Education.Children (Basel, Switzerland) · 2025Article
- Circadian clock dysfunction in Parkinson's disease: mechanisms, consequences, and therapeutic strategy.NPJ Parkinson's disease · 2025Review
- Feasibility of an At-Home Experimental Circadian Misalignment Induction for Adolescents.Clocks & sleep · 2025Article
- Feasibility of combining tDCS with exercise for increasing physical activity in people with depression.Frontiers in physiology · 2025Article
- Mapping the Connection Between Circadian Rhythms, Metabolism, and Neurodegeneration: Exploring Therapeutic Strategies.Current Alzheimer research · 2025Review
- Circadian Intervention Improves Parkinson's Disease and May Slow Disease Progression: A Ten Year Retrospective Study.Brain sciences · 2024Article
- Review
- The effects of time restricted feeding on age-related changes in the mouse retina.Experimental gerontology · 2024Article
- The cognitive impact of light: illuminating ipRGC circuit mechanisms.Nature reviews. Neuroscience · 2024Review
- Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature.Frontiers in physiology · 2024Article
- The Associations between the Homeostatic and Circadian Sleep Processes and the Neurobehavioral Functioning (NBF) of Individuals with ADHD-A Systematic Review.Brain sciences · 2023Review
- Cognitive Impairment in Multiple Sclerosis.Bioengineering (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.