Evidence map›Paper›PMID 35547489›Full record

ArticleRSC advances2018

Photosensitizer-loaded biomimetic platform for multimodal imaging-guided synergistic phototherapy.

Ying Tian, Ying Zhao, Wenfei Liu, Ying Liu, Yuxia Tang, Zhaogang Teng, Chunni Zhang, Shouju Wang, Guangming Lu

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ying TianDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Ying ZhaoDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Wenfei LiuDepartment of Respiration, Nanjing First Hospital, Nanjing Medical University Nanjing 210000 P. R. China.
Ying LiuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Yuxia TangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Zhaogang TengDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.ORCID https://orcid.org/0000-0001-8792-764X
Chunni ZhangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Shouju WangDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.
Guangming LuDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China zchunni27@hotmail.com shouju.wang@gmail.com cjr.luguangming@vip.163.com.ORCID https://orcid.org/0000-0003-0303-1489
Nanjing General Hospital of Nanjing Military Command · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) has attracted much attention as a strategy for tumor therapy. However, the insolubility and poor tumor-targeting ability of most photosensitizers (PSs) hinder PDT from further development. Therefore, it is necessary to explore new carriers with good water solubility and biocompatibility to deliver PSs to tumors. Melanin nanoparticles are novel biomimetic nanocarriers with excellent biocompatibility, loading capacity, photothermal therapy (PTT) and magnetic resonance (MR)/photoacoustic (PA) imaging properties. Here we designed polydopamine melanin nanoparticles (PDMNs) as a delivery platform for the photosensitizer Chlorin e6 (PDMN-Ce6) and realized its application as a theranostic agent for tumor therapy. The PDMN-Ce6 exhibited excellent biocompatibility, good water solubility and high loading capability (35.2 wt%) for Ce6. Compared with the free Ce6, PDMN-Ce6 showed higher cellular internalization and superior synergistic phototherapy effects in an

Identifiers

PMID35547489
PMCPMC9086261
OpenAlexW2891158688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.