ReviewCureus2022
Post-Operative Sensitivity and Color Change Due to In-Office Bleaching With the Prior Use of Different Desensitizing Agents: A Systematic Review.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Interventions for bleaching-induced tooth sensitivity: an umbrella review.Frontiers in oral health · 2026Pooled it
- Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.Clinical oral investigations · 2025Trial
- Bleaching efficacy and tooth sensitivity using violet LED - single-blind randomized controlled trial.Lasers in medical science · 2025Trial
- Evaluation of tooth sensitivity and whitening effects of tooth whitening agents containing calcium, hydroxyapatite and fluoride.Odontology · 2026Article
- To Bleach or Not to Bleach?-The Role of Bleaching in the Clinical Workflow for the Treatment of Demarcated Opacities in Anterior Teeth.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Evaluation of the effects of different remineralizing agents on the microhardness and mineral content of bleached enamel along different storage times.BMC oral health · 2026Article
- Comparative Assessment of Ibuprofen-Arginine and Potassium Nitrate-Fluoride Gels for Reducing Post-Bleaching Dentin Sensitivity: A Randomized, Double-Blind, Split-Mouth Trial.International journal of dentistry · 2026Article
- Effect of Glutaraldehyde-Based Desensitizer on Control of Tooth Sensitivity and Tooth Color Post-bleaching: A Randomized Clinical Trial.European journal of dentistry · 2025Article
- Effect of potassium nitrate on tooth sensitivity during in-office bleaching: A randomized clinical trial.Journal of clinical and experimental dentistry · 2025Article
- Evaluation of the Effectiveness of Different Types of Professional Tooth Whitening: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- A scanning electron microscope analysis on the effect of bleaching gel in combination with fluoro calcium phosphosilicate-based dentifrice on whitening of teeth and dentinal tubule occlusion - AnJournal of conservative dentistry and endodontics · 2024Article
- Comparative evaluation of bond strength of diode and neodymium-doped:Yttrium aluminum garnet-assisted bleached enamel with nanofilled composite: AnJournal of conservative dentistry and endodontics · 2024Article
- Efficacy of Tooth Bleaching With Prior Application of Two Different Desensitizing Agents: An In Vitro Study.Cureus · 2023Article
- Effects of laser irradiation and tooth mousse on tooth hypersensitivity after office bleaching: A non-randomized clinical trial.Dental research journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bleaching agents can cause certain surface alterations on the enamel, such as depressions, surface porosity, and surface irregularities; this makes the dentin more susceptible to post-operative tooth sensitivity (PoS). In addition, the presence of flawed or leaky restorations, gingival recession, or defects in the cementoenamel junction can also cause severe tooth sensitivity post tooth bleaching.Hence, the current study aimed to perform a systematic review to determine the efficacy of various desensitizing agents (DA) in managing post-operative tooth sensitivity and color alteration when applied before in-office bleaching procedures. Randomized clinical trials were searched to conduct an SR where the post-operative tooth sensitivity was evaluated after in-office bleaching with various desensitizing agents used before the procedure. Post-operative pain assessment was measured using the Visual Analogue Scale (VAS). Outcomes were evaluated up to an hour and 24 hours post the procedure. Out of 163 articles, only 13 titles were selected that met the eligibility criteria. Eight hundred and forty-one adult patients with vital pulp status were included. The participants receiving prior desensitizing agent applications reported significantly lower pain scores in the VAS reports. The most significant reduction of post-operative sensitivity was observed in the immediate (up to an hour) and 24 hours after the in-office bleaching. The popular desensitizing agent that could manage post-operative tooth sensitivity (TS) is 5% potassium nitrate and 2% sodium fluoride used before the in-office bleaching procedure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.