ReviewCureus2022
Common Sensitive Diagnostic and Prognostic Markers in Hepatocellular Carcinoma and Their Clinical Significance: A Review.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- miR-139-5p Targets CENPM to Suppress EMT and Malignant Progression of Hepatocellular Carcinoma via Regulating the Akt/mTOR Pathway and β-Catenin Nuclear Translocation.Journal of hepatocellular carcinoma · 2026Article
- [New progress in the technology of non-invasive diagnosis for small hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- Glycomics as prognostic biomarkers of hepatocellular carcinoma: A systematic review.Oncology letters · 2025Article
- A novel phosphodiesterase target as a therapeutic approach: inhibiting DEN-induced hepatocellular carcinoma progression.EXCLI journal · 2025Review
- Establishment of a multi-line immunochromatography based on magnetic nanoparticles for simultaneous screening of multiple biomarkers.Analytical and bioanalytical chemistry · 2024Article
- Development of a diagnostic nomogram for alpha-fetoprotein-negative hepatocellular carcinoma based on serological biomarkers.World journal of gastrointestinal oncology · 2024Article
- Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization.Molecular and clinical oncology · 2024Article
- Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.International journal of clinical and experimental pathology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver cancer is one of the most serious cancers that lead to death around the world. In Saudi Arabia, it represents 4.1% of all diagnosed cancers in 2020. The total survival rate for all stages of liver cancer is 15% at five years after diagnosis, and this can be affected by the available therapy. Hepatocellular carcinoma (HCC) is known to be the most prevalent primary malignant tumor of the liver, and several studies have been conducted to improve the management approach in the early and late stages. Biomarkers are a useful tool for early diagnosis, disease progression, prognosis, and targeted therapy for patients with liver cancer. The most important biomarker that has been studied is alpha-fetoprotein (AFP), which is elevated in 70% of patients with liver cancer. Also, des-gamma-carboxyprothrombin (DCP) is a more specific biomarker in HCC compared to AFP as it is elevated in HCC, which can be elevated in several conditions that cause active hepatitis. In addition, squamous cell carcinoma antigen (SCCA) and Golgi protein 73 (GP73) have high sensitivity compared to AFP and DCP but poor specificity. All of these markers are useful in the diagnosis, management, and prognosis prediction of liver cancer, especially the combination of AFP and DCP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.