Evidence map›Paper›PMID 35547396›Full record

ArticleFrontiers in molecular biosciences2022

Small Things Matter: The 11.6-kDa TraB Protein is Crucial for Antibiotic Resistance Transfer Among Enterococci.

Tamara M I Berger, Claudia Michaelis, Ines Probst, Theo Sagmeister, Lukas Petrowitsch, Sandra Puchner, Tea Pavkov-Keller, Bernd Gesslbauer, Elisabeth Grohmann, Walter Keller

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamara M I BergerInstitute of Molecular Biosciences, Department of Structural Biology, University of Graz, Graz, Austria.
Claudia MichaelisFaculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
Ines ProbstDivision of Infectious Diseases, University Medical Center Freiburg, Freiburg, Germany.
Theo SagmeisterInstitute of Molecular Biosciences, Department of Structural Biology, University of Graz, Graz, Austria.
Lukas PetrowitschInstitute of Molecular Biosciences, Department of Structural Biology, University of Graz, Graz, Austria.
Sandra PuchnerFaculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
Tea Pavkov-KellerInstitute of Molecular Biosciences, Department of Structural Biology, University of Graz, Graz, Austria.
Bernd GesslbauerInstitute of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Graz, Graz, Austria.
Elisabeth GrohmannFaculty of Life Sciences and Technology, Department of Microbiology, Berliner Hochschule für Technik, Berlin, Germany.
Walter KellerInstitute of Molecular Biosciences, Department of Structural Biology, University of Graz, Graz, Austria.

Funding

Austrian Science Fund FWF DOC 130Austrian Science Fund FWF DOC 50
6 · The paper itself

Abstract

Conjugative transfer is the most important means for spreading antibiotic resistance genes. It is used by Gram-positive and Gram-negative bacteria, and archaea as well. Conjugative transfer is mediated by molecular membrane-spanning nanomachines, so called Type 4 Secretion Systems (T4SS). The T4SS of the broad-host-range inc18-plasmid pIP501 is organized in a single operon encoding 15 putative transfer proteins. pIP501 was originally isolated from a clinical

Indexed as

antibiotic resistanceconjugative transferEnterococcusplasmidsecretion complextype IV secretion system

Identifiers

PMID35547396
PMCPMC9083827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.