ArticleFrontiers in neurology2022
Long-Term Outcome of Temporal Lobe Epilepsy Surgery in 621 Patients With Hippocampal Sclerosis: Clinical and Surgical Prognostic Factors.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Pooled it
- An examination of seizure-free outcome and visual field deficits: Anterior temporal lobectomy versus selective amygdalohippocampectomy for temporal lobe epilepsy-a systematic review and meta-analysis for comprehensive understanding.Acta neurochirurgica · 2024Pooled it
- Does classical semiology ("5As") predict post-operative seizure outcome in patients with temporal lobe epilepsy?Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Review
- Insulin-like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis.Epilepsia · 2026Article
- Temporal lobe disconnection in drug-resistant epilepsy associated with hippocampal sclerosis: how I do it.Acta neurochirurgica · 2026Article
- The epileptologist's perspective of focal cortical dysplasia type 3: From concept to management.Epilepsia · 2026Review
- Long-term predictors of seizure outcome after anterior temporal lobectomy in unilateral hippocampal sclerosis: A 281-patient cohort with mean 10-year follow-up.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Long-term memory trajectories in seizure-free patients following epilepsy surgery for hippocampal sclerosis.Epilepsia · 2026Article
- Epilepsy Surgery in Kazakhstan: Outcomes and the Role of Advanced Imaging.Journal of clinical medicine · 2025Article
- Main complications of epilepsy surgery performed in a single center in Latin America.Neurosurgical review · 2025Article
- Anterior temporal lobectomy and selective AmygdaloHippocampectomy complications across Europe: review, meta-analysis, and Delphi consensus.Brain & spine · 2025Review
- Cell therapy for neurological disorders.Nature medicine · 2024Review
- Resective surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis in patients over 50 years: a case-control study.Journal of neurology · 2024Article
- Identification of four biotypes in temporal lobe epilepsy via machine learning on brain images.Nature communications · 2024Article
- Stereotactic Electroencephalogram Recordings in Temporal Lobectomy Patients Demonstrates the Predictive Value of Interictal Cross-Frequency Correlations: A Retrospective Study.Brain sciences · 2024Article
- Stereo-electroencephalographic seizure localization in patients with mesial temporal sclerosis: A single center experience.Clinical neurophysiology practice · 2024Article
- Mesial temporal lobe epilepsy and hippocampal sclerosis associated withFree neuropathology · 2024Article
- Is there room in epilepsy for the claustrum?Frontiers in systems biology · 2024Article
- MR-Guided Focused Ultrasound for Refractory Epilepsy: Where Are We Now?Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy and is frequently drug-resistant (DR) to antiseizure medication (ASM), corresponding to approximately one-third of the cases. When left inadequately treated, it can worsen the quality of life, cognitive deficits, and risk of death. The standard treatment for drug-resistant TLE is the surgical removal of the structures involved, with good long-term outcome rates of 60-70 % and a low rate of adverse effects. The goal of successful treatment is sustained seizure freedom. In our study, we evaluated sustained long-term (up to 23 years) surgical outcomes in 621 patients with DR-TLE associated with hippocampal sclerosis, who underwent a temporal lobectomy. We analyzed the main predictive factors that influence the surgical outcome related to seizure control, through a longitudinal and retrospective study, using a multivariable regression model. We found that 73.6% of the patients were free from disabling seizures (Engel Class I), maintained over time in 65% of patients followed up to 23 years after surgery. We found that four independent variables predicted seizure outcomes. The presence of dysmnesic and olfactory aura predicted a less favorable outcome. The history of febrile seizure and the surgical technique predicted a good outcome. Regarding the type of surgical technique, the standard anteromesial temporal lobectomy (ATL) led to significantly better outcomes (78.6% Engel Class I) when compared to the selective amygdalohippocampectomy
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