ArticleFrontiers in medicine2022
Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Presurgical immune biomarkers associated with pain intensity and pain interference recovery after total knee arthroplasty: findings from the PRIME-KNEE study.medRxiv : the preprint server for health sciences · 2026Article
- Review
- A Multiplexed Quantitative Analysis of Germline Single Amino Acid Variants by Targeted Proteomics in Nondepleted Human Plasma.Journal of proteome research · 2026Article
- Convergent and selective representations of pain, appetitive processes, aversive processes, and cognitive control in the insula.Nature communications · 2026Article
- MV-ComBat and MV-CovBat: Multivariate Frameworks for Joint Harmonization of Multi-Metric Neuroimaging Data.bioRxiv : the preprint server for biology · 2026Article
- Data Quality Assurance Tool for the Acute to Chronic Pain Signatures Study (A2CPS): An Interactive R Shiny Application.medRxiv : the preprint server for health sciences · 2026Article
- Prediction Models for Acute and Chronic Postoperative Pain in Patients with Cancer: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
- A Multilateral Qualitative Study of Perspectives on Enhancing Clinical Trial Diversity Among Historically Underrepresented Groups.Clinical therapeutics · 2025Article
- Review
- Why PNI scientists need to engage in exploratory hypothesis-generating biomarker studies.Brain, behavior, & immunity - health · 2024Article
- Michigan body map: connecting the NIH HEAL IMPOWR network to the HEAL ecosystem.Pain medicine (Malden, Mass.) · 2023Article
- Next-generation DNA methylation sequencing: loci and regions differentially methylated in adolescents with chronic postsurgical pain.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
45 authors at 17 institutions in 1 country.
Funding
Abstract
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or "omics," quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.