ArticleRSC advances2020
Water-based synthesis of photocrosslinked hyaluronic acid/polyvinyl alcohol membranes
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- PVA Nanofibers by Solution Blow Spinning: Processing Principles, Challenges, and Biomedical Applications.Polymers · 2026Review
- Hyaluronan open-pit nanofibrils with spontaneous cell-matrix assembly for advanced osteochondral defect repair.Materials today. Bio · 2026Article
- Article
- Marine Biomaterials: Hyaluronan.Marine drugs · 2023Review
- Electrospun Nanofibrils Surface-Decorated with Photo-Cross-Linked Hyaluronic Acid for Cell-Directed Assembly.ACS omega · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrospinning is a versatile and low-cost technique widely used in the manufacture of nanofibrous polymeric membranes applied in different areas, especially in bioengineering. Hyaluronic acid (HA) is a biocompatible natural polymer, but it has rheological characteristics that make the electrospinning process difficult. Thus, its association with another polymer such as poly(vinyl alcohol) (PVA) is an alternative, as PVA has good rheological properties for electrospinning. Based on this, the aim of this work was to produce, by the conventional electrospinning method, cross-linked HA/PVA membranes free from organic solvent with a low degradation rate in PBS 7.4 solution after the photocrosslinking process and without using any organic solvent. The results showed that the electrospinning occurred effectively for all conditions tested, but the best result for complete cross-linking only occurred with 15 and 30% crosslinker, which was evidenced by infrared spectroscopy. The addition of crosslinker favored the stability of the electrospinning jet, especially for 30% crosslinker concentration. The membranes did not show cytotoxicity even after the cross-linking process, which indicates that the material has potential as a drug delivery device.
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Registered trials
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