Evidence map›Paper›PMID 35547003›Full record

ArticleFrontiers in endocrinology2022

Outcome of Endoscopic Transsphenoidal Surgery for Recurrent or Residual Pituitary Adenomas and Comparison to Non-Recurrent or Residual Cohort by Propensity Score Analysis.

Xuan Gong, Yang Zhuo, Huichun Yuan, Kui Yang, Chuntao Li, Songshan Feng, Mingyu Zhang, Zhenyan Li, Hongshu Zhou, Zhixiong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Evolution of Pituitary Surgery in an Australian Health Care Framework.Journal of neurological surgery. Part B, Skull base · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xuan GongDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Yang ZhuoDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Huichun YuanDepartment of Neurosurgery, The First People's Hospital of Changde, Changde, China.
Kui YangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Chuntao LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Songshan FengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Mingyu ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Zhenyan LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Hongshu ZhouDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Zhixiong LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNThe First People's Hospital of Changde · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate the long-term outcomes and safety of endoscopic transsphenoidal surgery (ETS) in recurrent and residual pituitary adenomas (rrPAs), as well as the predictors of gross total resection (GTR) and intraoperative CSF leakage. Furthermore, to compare outcomes and complications with non-rrPAs cohort. Methods: Clinical and radiological characteristics of patients with rrPAs who underwent ETS were collected between 2017 and 2020. Data of patients with non-rrPAs were collected from 2019 to 2020. Logistic regression analyses were performed to investigate the factors influencing gross total resection (GTR) and intraoperative CSF leakage. Between-group comparisons of outcomes and complications were performed through propensity score analysis. Results: We enrolled 73 patients with rrPAs. GTR was achieved in 41 (56.1%) cases; further, GTR or near-total resection was achieved in 93.2% of patients. The mean tumor volumes for GTR and non-GTR cases were 6.2 ±7.2 cm Conclusions: Knosp grade was an independent factor for GTR in endoscopic transsphenoidal surgery in patients with rrPAs. Previous transcranial surgery and non-functional PAs were risk factors for intraoperative CSF leakage. Although associated with longer hospital stay, rrPAs did not associate with lower GTR rate or more frequent postoperative complications than non-rrPAs cohort.

Indexed as

AdenomaHypopituitarismPituitary NeoplasmsHumansPropensity ScoreRetrospective StudiesTreatment Outcomeendonasal endoscopic surgerygross total resectionpituitary adenomarecurrencerepeat transsphenoidal surgery

Identifiers

PMID35547003
PMCPMC9081813
OpenAlexW4224323448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.