ArticleFrontiers in neuroscience2022
Early-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Acute Sleep Deprivation in Adolescence Produces Transcriptional Changes in the Orexin System and Regulates Motivation for Reward.Biological psychiatry global open science · 2026Article
- Dualistic and inconsistent role of total and rapid-eye movement (REM) sleep deprivation on depressive-like behaviors in rats: a systematic review.Sleep and biological rhythms · 2025Review
- Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025Article
- Nucleus accumbens dynamics in food reward seeking and regulation by sleep.Translational psychiatry · 2025Article
- Effect of chronic sleep restriction on ethanol preference and cortical structural plasticity.Neurobiology of sleep and circadian rhythms · 2025Article
- Introduction of novel objects to the home cage of mice repeatedly disturbs sleep for seven days with minimal stress induction.Npj biological timing and sleep · 2025Article
- Article
- Long-lasting effects of disturbing the circadian rhythm or sleep in adolescence.Brain research bulletin · 2024Review
- Effect of high-intensity interval training on self-care and anxiety-like behaviors in naive rats.Experimental brain research · 2024Article
- Adolescent sleep and its disruption in depression and anxiety.Frontiers in neuroscience · 2024Review
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence in the literature suggests that sleep deprivation during early-life developmental stages, by impacting important processes such as the reward circuit maturation, may increase the vulnerability for alcohol and substance use. The mechanisms involved are not fully understood. In this study, utilizing our previously established model, we examined the impact of early-life sleep deprivation on alcohol consumption in adolescent rats. Male Sprague Dawley rats served as either the control (CON) or sleep-deprived (SD) group. Sleep deprivation was induced using a Pinnacle automated sleep deprivation apparatus. The SD group of rats was sleep deprived for 6-8 h/day for 14 days from postnatal day (PND)19 to PND32. At PND33, anxiety- and depression-like behaviors were assessed in rats using elevated plus maze and sucrose splash test, respectively. At PND39, alcohol consumption was assessed in rats for five consecutive days using the two-bottle choice paradigm, water versus 5% ethanol. SD rats exhibited significant anxiety- and depression-like behaviors as compared to CON rats. Interestingly, SD rats consumed a larger volume of alcohol when compared to CON rats, which was significantly higher at day 5 (mean of alcohol consumption (ml) ± SD; CON = 6.67 ± 3.42; SD = 19.00 ± 6.05,
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