Evidence map›Paper›PMID 35546633›Full record

Trial reportMolecular psychiatry2022

The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study.

Antoine Rogeau, Giovanna Nordio, Mattia Veronese, Kirsten Brown, Matthew M Nour, Martin Osugo, Sameer Jauhar, Oliver D Howes, Robert A McCutcheon

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Antoine RogeauDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3993-3954
Giovanna NordioDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-3562-0683
Kirsten BrownDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Matthew M NourMax Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.ORCID http://orcid.org/0000-0003-0858-6184
Martin OsugoDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Sameer JauharDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3878-3659
Oliver D HowesDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Robert A McCutcheonDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. robert.mccutcheon@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1102-2566
King's College London · GBProstate Cancer Research · GBUniversity of Padua · IT

Funding

Department of HealthMedical Research Council G0700995Medical Research Council MC_PC_19041Medical Research Council MC_U120097115Medical Research Council MR/N026063/1Medical Research Council MR/N027078/1Medical Research Council MR/V013734/1Wellcome Trust 094849/Z/10/ZWellcome Trust 102186/B/13/ZWellcome Trust 200102/Z/15/ZWellcome Trust 215747/Z/19/Z
6 · The paper itself

Abstract

Prefrontal cortex has been shown to regulate striatal dopaminergic function via glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine signaling, cortical gray matter, and glutamate levels is therefore of major interest, but has not been previously reported. In the current study, twenty-eight healthy subjects underwent 2 simultaneous [

Indexed as

DopamineGray MatterCorpus StriatumGlutamic AcidHumansMagnetic Resonance ImagingPositron-Emission TomographyReceptors, Dopamine D2DopamineGlutamic AcidReceptors, Dopamine D2

Identifiers

PMID35546633
PMCPMC9708555
OpenAlexW4280517603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.