ArticleNature communications2022
Translaminar recurrence from layer 5 suppresses superficial cortical layers.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
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- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.The Journal of physiology · 2026Article
- Ionic Direct Current Enables Millimeter- and Millisecond-Scale Cortical Gain Control in vivo.bioRxiv : the preprint server for biology · 2025Article
- Layered structure of cortex explains reversal dynamics in bistable perception.Scientific reports · 2025Article
- Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.Current biology : CB · 2025Article
- SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.Nature communications · 2025Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Article
- Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.Nature communications · 2024Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Distractor inhibition by alpha oscillations is controlled by an indirect mechanism governed by goal-relevant information.Communications psychology · 2024Review
- Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.Nature communications · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- Biological constraints on stereotaxic targeting of functionally-defined cortical areas.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Information flow in the sensory cortex has been described as a predominantly feedforward sequence with deep layers as the output structure. Although recurrent excitatory projections from layer 5 (L5) to superficial L2/3 have been identified by anatomical and physiological studies, their functional impact on sensory processing remains unclear. Here, we use layer-selective optogenetic manipulations in the primary auditory cortex to demonstrate that feedback inputs from L5 suppress the activity of superficial layers regardless of the arousal level, contrary to the prediction from their excitatory connectivity. This suppressive effect is predominantly mediated by translaminar circuitry through intratelencephalic neurons, with an additional contribution of subcortical projections by pyramidal tract neurons. Furthermore, L5 activation sharpened tone-evoked responses of superficial layers in both frequency and time domains, indicating its impact on cortical spectro-temporal integration. Together, our findings establish a translaminar inhibitory recurrence from deep layers that sharpens feature selectivity in superficial cortical layers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.