SynthesisAging cell2022
Integrative analysis of clinical and epigenetic biomarkers of mortality.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation.Nature communications · 2025Pooled it
- Pooled it
- Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque.Molecular ecology · 2025Article
- ECM formation and degradation during fibrosis, repair, and regeneration.npj metabolic health and disease · 2025Review
- Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty.Aging and disease · 2025Article
- Clinical promise and applications of epigenetic biomarkers.Clinical epigenetics · 2024Article
- Associations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults.Life (Basel, Switzerland) · 2024Article
- Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome.Epigenetics · 2024Article
- DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes.Cardiovascular diabetology · 2024Article
- The Application of Mendelian Randomization in Cardiovascular Disease Risk Prediction: Current Status and Future Prospects.Reviews in cardiovascular medicine · 2024Review
- Epigenetic Age Mediates the Association of Life's Essential 8 With Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2024Article
- Neighborhood Disadvantage and Parenting in Early Adolescence Predict Epigenetic Aging and Mortality Risk in Adulthood.Journal of youth and adolescence · 2024Article
- Validation of biomarkers of aging.Nature medicine · 2024Review
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 9 countries.
Tianxiao HuanThe Framingham Heart Study, Framingham, Massachusetts, USA.
Steve NguyenDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Elena ColicinoIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Carolina Ochoa-RosalesDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
W David HillDepartment of Psychology, Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Mette SoerensenDepartment of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Yan ZhangDivision of Clinical Epidemiology & Aging Research, German Cancer Rsrch Ctr (DKFZ), Heidelberg, Germany.
Antoine BaldassariDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Mohamed Ahmed ElhadadResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Tanaka ToshikoTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Arce Domingo-RellosoDepartment of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.
Dong Heon LeeThe Framingham Heart Study, Framingham, Massachusetts, USA.
Jiantao MaThe Framingham Heart Study, Framingham, Massachusetts, USA.
Chen YaoThe Framingham Heart Study, Framingham, Massachusetts, USA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Shih-Jen HwangThe Framingham Heart Study, Framingham, Massachusetts, USA.
Roby JoehanesThe Framingham Heart Study, Framingham, Massachusetts, USA.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jan BresslerDepartment of Internal Medicine, Erasmus, Rotterdam, the Netherlands.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus, Rotterdam, the Netherlands.
Birgit DebrabantDepartment of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Jonas Mengel-FromDepartment of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Jacob HjelmborgDepartment of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Kaare ChristensenDepartment of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense C, Denmark.
Pantel VokonasVeterans Affairs, Normative Aging Study, Boston, Massachusetts, USA.
Joel SchwartzDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Sina A GahribCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Sonja KunzeResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Ian J DearyDivision of Pulmonary, Critical Care and Sleep Medicine, Center for Lung Biology, University of Washington, Seattle, Washington, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Yishu QuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Stefania BandinelliGeriatric Unit, LHATC (Local Health Authorities Tuscany Centre), Florence, Italy.
Trudy VoortmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Brenner HermannDivision of Clinical Epidemiology & Aging Research, German Cancer Rsrch Ctr (DKFZ), Heidelberg, Germany.
Andrea BaccarelliPrecision Medicine Program, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Eric WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
James S PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Daniel LevyThe Framingham Heart Study, Framingham, Massachusetts, USA.ORCID 0000-0003-1843-8724
National Institutes of Health · USHelmholtz Zentrum München · DENorthwestern University · USUniversity of Southern Denmark · DKUniversity of Washington · USBoston University · USErasmus University Rotterdam · NLGerman Cancer Research Center · DENational Institute on Aging · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USColumbia University · USErasmus MC · NLIcahn School of Medicine at Mount Sinai · USMassachusetts Department of Public Health · USNHS Lothian · GBThe University of Texas Health Science Center at Houston · USTufts University · USTumour Institute of Tuscany · ITUniversitat de València · ES
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MProspective meta-analyses of drug-gene interactions: CHARGE GWAS consortiumR01HL103612 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2011 to 2014
$5.4MGenome-wide study of sudden cardiac arrest in the communityR01HL092111 · NHLBI · UNIVERSITY OF WASHINGTON · PI SOTOODEHNIA, NONA · 2009 to 2011
$5.3MWGA Study to Identify Genetic Variants Associated with CV Events in CHSR01HL087652 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2009
$5.1MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MMedical Research Council G0700704Medical Research Council MR/K026992/1Medical Research Council MR/T030852/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR001881NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL116640NHLBI NIH HHS K08HL116640NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01HL087652NHLBI NIH HHS R01 HL092111NHLBI NIH HHS R01HL092111NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01HL080295NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01HL130114NIA NIH HHS R01 AG023629NIA NIH HHS R01AG023629NIA NIH HHS T32 AG058529NIDDK NIH HHS P30 DK063491NIH HHS HHSN268201500001INIH HHS N01-HC-25195
Abstract
DNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n = 15,013). During a mean follow-up of 10 years, there were 4314 deaths from all causes including 1235 cardiovascular disease (CVD) deaths and 868 cancer deaths. Ancestry-stratified meta-analysis of all-cause mortality identified 163 CpGs in European ancestry (EA) and 17 in African ancestry (AA) participants at p < 1 × 10
Indexed as
Cardiovascular DiseasesNeoplasmsBiomarkersDNA MethylationEpigenesis, GeneticEpigenomicsHumansMaleBiomarkerscancercardiovascular diseaseDNA methylationmachine learningmortality
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