Evidence map›Paper›PMID 35546359›Full record

ArticleJournal of cancer research and clinical oncology2023

Prediction model of 3-year survival after endoscopic submucosal dissection for early gastric cancer in elderly patients aged ≥ 85 years: EGC-2 model.

Yosuke Toya, Tomohiro Shimada, Koichi Hamada, Ko Watanabe, Jun Nakamura, Daisuke Fukushi, Waku Hatta, Hirohiko Shinkai, Hirotaka Ito, Tamotsu Matsuhashi and 31 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. Nutritional Strategies for Patients With Upper Gastrointestinal Cancers.The Korean journal of helicobacter and upper gastrointestinal research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 1 country.

Yosuke ToyaDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Idaidori 1-1-1, Yahaba, 028-3694, Japan. ytoya@iwate-med.ac.jp.ORCID http://orcid.org/0000-0002-0990-9304
Tomohiro ShimadaDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
Koichi HamadaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Ko WatanabeDepartment of Gastroenterology, Ohara General Hospital, Fukushima, Japan.
Jun NakamuraDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Daisuke FukushiDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Waku HattaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirohiko ShinkaiDepartment of Gastroenterology, Iwate Prefectural Isawa Hospital, Oshu, Japan.
Hirotaka ItoDepartment of Gastroenterology, Osaki Citizen Hospital, Osaki, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Shusei FujimoriDepartment of Gastroenterology, Yokote Municipal Hospital, Yokote, Japan.
Wataru IwaiDepartment of Gastroenterology, Miyagi Cancer Center, Natori, Japan.
Norihiro HanabataDivision of Endoscopy, Aomori Prefectural Central Hospital, Aomori, Japan.
Takeharu ShirokiDepartment of Gastroenterology, Iwate Prefectural Central Hospital, Morioka, Japan.
Yu SasakiDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Yuukou FujishimaDivision of Gastroenterology, Noshiro Kosei Medical Center, Noshiro, Japan.
Tsuyotoshi TsujiDepartment of Gastroenterology, Akita City Hospital, Akita, Japan.
Haruka YorozuDigestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
Tetsuro YoshimuraDivision of Gastroenterology, Aomori City Hospital, Aomori, Japan.
Yohei HorikawaDepartment of Gastroenterology, Hiraka General Hospital, Yokote, Japan.
Yasushi TakahashiDepartment of Gastroenterology, National Hospital Organization Sendai Medical Center, Sendai, Japan.
Hiroshi TakahashiDepartment of Gastroenterology, Iwate Prefectural Ninohe Hospital, Ninohe, Japan.
Yutaka KondoDivision of Gastroenterology, Tohoku Rosai Hospital, Sendai, Japan.
Takao FujiwaraDepartment of Gastroenterology, Japanese Red Cross Morioka Hospital, Morioka, Japan.
Hisata MizugaiDepartment of Gastroenterology, Hachinohe Red Cross Hospital, Hachinohe, Japan.
Takahiro GonaiDepartment of Gastroenterology, Iwate Prefectural Kuji Hospital, Kuji, Japan.
Tetsuya TatsutaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kengo OnochiDepartment of Gastroenterology, Omagari Kosei Medical Center, Daisen, Japan.
Norihiko KudaraDepartment of Internal Medicine and Gastroenterology, Iwate Prefectural Ofunato Hospital, Ofunato, Japan.
Keinosuke AbeDepartment of Gastroenterology, Iwate Prefectural Miyako Hospital, Miyako, Japan.
Tetsuya OhiraDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
Yoshinori HorikawaDepartment of Gastroenterology, Southern-Tohoku General Hospital, Fukushima, Japan.
Ryoichi IshihataDepartment of Gastroenterology, Ohara General Hospital, Fukushima, Japan.
Takuto HikichiDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Kennichi SatohDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Fumiaki TakahashiDivision of Medical Engineering, Department of Information Science, School of Medicine, Iwate Medical University, Yahaba, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Katsunori IijimaDepartment of Gastroenterology and Neurology, Akita University Graduate School of Medicine, Akita, Japan.
Shinsaku FukudaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Idaidori 1-1-1, Yahaba, 028-3694, Japan.
Tohoku GI Endoscopy Group
Iwate Prefectural Central Hospital · JPIwate Medical University · JPSendai Medical Center · JPAkita University · JPFukushima Medical University Hospital · JPHiraka General Hospital · JPHirosaki University · JPSeirei Hamamatsu General Hospital · JPTohoku Medical and Pharmaceutical University · JPTohoku University · JPAkita Red Cross Hospital · JPAkita University Hospital · JPAomori Prefectural Central Hospital · JPAomori Rosai Hospital · JPFukushima Medical University · JPJapanese Red Cross Hadano Hospital · JPMiyagi Prefectural Hospital Organization · JPNagaoka Red Cross Hospital · JPOsaki Citizen Hospital · JPTohoku Rosai Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLittle is known about the prognostic factors for survival after endoscopic submucosal dissection (ESD) in elderly patients with early gastric cancer (EGC). The aim of this study is to determine prognostic factors and a prediction model of 3-year survival after ESD for EGC in patients aged ≥ 85 years.

methodsWe retrospectively evaluated the clinical outcomes of 740 patients with EGC aged ≥ 85 years, who were treated by ESD at 30 institutions in Japan. Overall survival (OS) and disease-specific survival (DSS) were calculated with the Kaplan-Meier method. Prediction models for 3-year OS after ESD were estimated using the Cox proportional hazards model based on Uno's C-statistics.

resultsDuring the follow-up period, 309 patients died of any cause and 10 patients died of gastric cancer. OS and DSS after 3 years were 82.7% and 99.2%, respectively. No significant differences in OS were found among curability categories. The Cox proportional hazards model revealed the geriatric nutritional risk index (GNRI) and the Charlson comorbidity index (CCI) to be predictors of 3-year survival. We established a final model (EGC-2 model) expressed by GNRI - (2.2×CCI) with a cutoff value of 96. The overall survival rate was significantly lower in the model value < 96 group than in the model value ≥ 96 group (P < 0.001).

conclusionsThe prediction model using GNRI and CCI will be useful to support decision-making for the treatment of EGC in elderly patients aged ≥ 85 years.

Indexed as

Endoscopic Mucosal ResectionStomach NeoplasmsAgedEarly Detection of CancerGastrectomyGastric MucosaHumansRetrospective StudiesTreatment OutcomeElderly patientsEndoscopic submucosal dissectionGastric cancerPrognostic factors

Identifiers

PMID35546359
PMCPMC11797289
OpenAlexW4280508779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.