ArticleNature communications2022
Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Photocatalyzed Aerobic Oxidation of Thiols to Disulfides Using CuACS applied materials & interfaces · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- An innovative strategy for radical-mediated, bidirectional controlled disulfide exchange.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Photo-induced decarboxylative C-S bond formation to access sterically hindered unsymmetric S-alkyl thiosulfonates and SS-alkyl thiosulfonates.Nature communications · 2024Article
- Ligand Relay for Nickel-Catalyzed Decarbonylative Alkylation of Aroyl Chlorides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Seed free synthesis of polyethylene glycol stabilized gold nanoprisms exploiting manganese metal at low pH.Nanoscale advances · 2023Article
- Electrochemical radical-mediated selective C(spChemical science · 2023Article
- Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols.Nature communications · 2022Article
- Dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new S-donor for direct synthesis of symmetrical disulfides.Scientific reports · 2022Article
- Homocouplings of Sodium Arenesulfinates: Selective Access to Symmetric Diaryl Sulfides and Diaryl Disulfides.Molecules (Basel, Switzerland) · 2022Article
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5 authors.
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Abstract
Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds. This strategy has many side reactions and other shortcomings. Herein, we describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with symmetrical alkyl- and aryltetrasulfides to form alkyl-alkyl and aryl-alkyl unsymmetrical disulfides. This approach for disulfide synthesis is practical, relies on easily available, unfunctionalized substrates, and is scalable. We investigated the mechanism of this transformation and found that the tetrasulfide compound does not selectively break the central S-S bond, but regio-selectively generates trisulfide intermediates.
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