ArticleHaematologica2023
COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA).
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Haematologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- 30 years in service, 1996-2026: Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of hematology · 2026Review
- Inpatient Hemato-Oncology Service Use Before, During, and After COVID-19 Restrictions in a Romanian Tertiary Center.Cureus · 2026Article
- One size does not fit all: A comparative framework for optimizing ribonucleic acid transfection across acute myeloid leukemia cell lines.Biology methods & protocols · 2026Article
- Spontaneous Remission of Acute Myeloid Leukemia With MutatedCase reports in hematology · 2026Article
- Article
- Immunogenicity of COVID-19 Vaccination in Immunocompromised Patients (Auto-COVID-VACC): Protocol for Multicenter Prospective Noninterventional Study.JMIR research protocols · 2025Article
- Review
- Clinical Characteristics of SARS-COV-2 Omicron Variant in Acute Myeloid Leukemia and Acute Lymphocytic Leukemia Patients: A Multi-Center Retrospective Study.Cancer reports (Hoboken, N.J.) · 2025Article
- Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.American journal of hematology · 2025Article
- Successful remission induction therapy with azacitidine and venetoclax for a treatment-naive elderly patient with ETP/myeloid mixed-phenotype acute leukemia: a case report.Frontiers in oncology · 2025Article
- Economic Burden of Intravenous Decitabine Administration in Patients Affected by Acute Myeloid Leukemia Ineligible for Induction Chemotherapy and Impact of Oral Formulation Introduction: A Micro-Costing Study in Italy.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Impact of COVID-19 on the Clinical Characteristics and Outcomes of Patients with Acute Leukaemia: An academic centre experience.Sultan Qaboos University medical journal · 2024Article
- The impact of COVID-19 on microRNA and CD marker expression in AML patients.Scientific reports · 2024Article
- Assessing the impact of COVID-19 on acute leukemia patients: a comparative analysis of hematological and biochemical parameters.BMC infectious diseases · 2024Article
- Managing and treating COVID-19 in patients with hematological malignancies: a narrative review and expert insights.Clinical and experimental medicine · 2024Review
- Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey.Infection · 2024Article
- Decoding the historical tale: COVID-19 impact on haematological malignancy patients-EPICOVIDEHA insights from 2020 to 2022.EClinicalMedicine · 2024Article
- COVID-19 in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): a propensity matched analysis (2020-2021).Frontiers in oncology · 2024Article
- Real-Life Comparison of Antivirals for SARS-CoV-2 Omicron Infection in Patients With Hematologic Malignancies.Influenza and other respiratory viruses · 2024Article
- Developing a novel SARS-CoV-2 risk index to predict the prognostic and therapeutic effects in acute myeloid leukemia.Heliyon · 2023Article
Corrections and comments
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Authors and funding
93 authors at 20 institutions in 27 countries.
Francesco MarchesiHematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome.
Jon Salmanton-GarcíaUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne. jon.salmanton-garcia@uk-koeln.de.
Ziad EmarahOncology Center, Mansoura University, Mansoura.
Klára PiukovicsDepartment of Internal Medicine, South Division Faculty of Medicine University of Szeged, Szeged.
Marcio NucciDepartment of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro.
Alberto López-GarcíaFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid.
Zdeněk RáčilInstitute of Hematology and Blood Transfusion, Prague, Czech Republic Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; IRCCS Ospedale San Raffaele, Milan.
Francesca FarinaIRCCS Ospedale San Raffaele, Milan.
Marina PopovaRM Gorbacheva Research Institute, Pavlov University, St. Petersburg.
Sofia ZompiStem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin.
Ernesta AudisioStem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin.
Marie-Pierre LedouxICANS, Strasbourg.
Luisa VergaAzienda Ospedaliera San Gerardo - Monza, Monza, Italy Università Milano-Bicocca, Milan.
Barbora WeinbergerováUniversity Hospital Brno - Department of Internal Medicine, Hematology and Oncology, Brno, Czech Republic.
Tomas SzotkovskiUniversity Hospital Olomouc, Olomouc, Czech Republic.
Maria Gomes Da SilvaPortuguese Institute of Oncology, Lisbon.
Nicola FracchiollaHematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
Nick De JongeAmsterdam UMC, location VUmc, Amsterdam.
Graham CollinsOxford University Hospitals, Oxford.
Monia MarchettiAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria.
Gabriele MaglianoASST Grande Ospedale Metropolitano Niguarda, Milan.
Carolina García-VidalDepartment of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona.
Monika M BiernatDepartment of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw.
Jaap Van DoesumUniversity Medical Center Groningen, Groningen.
Marina MachadoClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid.
Fatih DemirkanDokuz Eylul University, Division of Hematology, Izmir.
Murtadha Al-KhaboriSultan Qaboos University Hospital, Muscat.
Pavel ŽákUniversity Hospital Hradec Králové, Hradec Králové, Czech Republic.
Benjamín VíšekUniversity Hospital Hradec Králové, Hradec Králové, Czech Republic.
Igor StomaGomel State Medical University, Gomel.
Gustavo-Adolfo MéndezHospital Escuela de Agudos Dr. Ramón Madariaga, Posadas.
Johan MaertensDepartment of Microbiology, Immunology, and Transplantation, KULeuven, Leuven and Department of Hematology, UZ Leuven, Leuven.
Nina KhannaDivision of Infectious Diseases and Hospital Epidemiology, and Department of Clinical Research, University and University Hospital of Basel, Basel.
Ildefonso EspigadoDepartment of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS / CSIC), Universidad de Sevilla (Departamento de Medicina), Seville.
Giulia DragonettiHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome.
Luana FianchiHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome.
Maria Ilaria Del PrincipeHematology Unit, Department of Biomedicine and Prevention, Tor Vergata University of Rome.
Alba CabirtaDepartment of Hematology, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra.
Irati Ormazabal-VélezComplejo Hospitalario de Navarra, Iruña-Pamplona.
Ozren JaksicUniversity Hospital Dubrava, Zagreb, Croatia.
Caterina BuquicchioEmatologia con Trapianto, Ospedale Dimiccoli Barletta, Barletta.
Valentina BonuomoDepartment of Medicine, Section of Hematology, University of Verona, Verona.
Josip BatinićUniversity Hospital Centre Zagreb, Zagreb, Croatia Croatian Cooperative Group for Hematological Diseases (CROHEM), Croatia Faculty of Medicine University of Zagreb, Zagreb, Croatia.
Ali S OmraniHamad Medical Corporation, Division of Infectious Diseases, Doha.
Sylvain LamureDépartement d'Hématologie Clinique, CHU de Montpellier, UMR-CNRS 5535, Universite de Montpellier, Montpellier.
Olimpia FinizioUOC Hematology, AORN Cardarelli, Naples.
Noemí FernándezHospital Universitario Marqués de Valdecilla, Santander.
Iker Falces-RomeroLa Paz University Hospital, Madrid.
Ola BlennowDepartment of Infectious Diseases, Karolinska University Hospital, Stockholm.
Rui BergantimCentro Hospitalar e Universitário São João, Porto.
Natasha AliAga Khan University Hospital, Karachi.
Sein WinDepartment of Clinical Haematology, Yangon General Hospital, University of Medicine, Yangon.
Jens Van PraetDepartment of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge.
Maria Chiara TisiOspedale San Bortolo, Vicenza.
Ayten ShirinovaAzerbaijan Scientific Research Hematology and Transfusilogy Institute, Baku.
Martin SchönleinDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg.
Juergen PrattesMedical University of Graz, Department for Infectious Diseases, Graz.
Monica PiedimonteAOU Sant'Andrea, Rome.
Verena PetzerDepartment of Hematology and Oncology, Medical University of Innsbruck, Innsbruck.
Milan NavrátilHead of the ICU and Transplant Unit, Department of Hematooncology, University Hospital of Ostrava, Ostrava-Poruba, Czech Republic.
Austin KulasekararajKing's College Hospital, London.
Pavel JindraUniversity Hospital Pilsen, Pilsen, Czech Republic.
Jiří SramekDepartment of Hematology and Oncology, University Hospital Pilsen, Czech Republic Department of Histology and Embryology, Faculty of Medicine, Pilsen, Czech Republic.
Andreas GlenthøjDepartment of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen.
Rita FazziAOUP - Azienda Ospedaliera Università Pisana - Cisanello, Pisa.
Cristina De Ramón-SánchezHematology Department, Hospital Universitario de Salamanca, Salamanca, Spain IBSAL, Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca.
Chiara CattaneoHematology Unit, ASST-Spedali Civili, Brescia.
Maria CalbachoHospital Universitario 12 de Octubre, Madrid.
Nathan C BahrUniversity of Kansas Medical Center, Kansas City.
Shaimaa El-AshwahOncology Center, Mansoura University, Mansoura.
Raul CordobaFundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid.
Michaela HanakovaInstitute of Hematology and Blood Transfusion, Prague, Czech Republic.
Giovanni ZambrottaAzienda Ospedaliera San Gerardo - Monza, Monza, Italy Università Milano-Bicocca, Milan.
Mariarita SciumèHematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
Stephen BoothOxford University Hospitals, Oxford.
Raquel Nunes RodriguesPortuguese Institute of Oncology, Lisbon.
Maria Vittoria SacchiAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria.
Nicole García-PoutónDepartment of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona.
Juan-Alberto Martín-GonzálezHospital Univesitario Virgen del Rocío, Seville.
Sofya KhostelidiNorth-Western State Medical University named after Iliá Ilich Méchnikov, Saint-Petersburg.
Stefanie GräfeUniversitätsklinikum Hamburg Eppendorf, Hamburg, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne.
Laman RahimliUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne.
Emanuele AmmatunaUniversity Medical Center Groningen, Groningen.
Alessandro BuscaStem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin.
Paolo CorradiniUniversity of Milan and Fondazione IRCCS Istituto Nazionale dei Tumori, Milan.
Martin HoeniglDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA, United States Clinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, CA, United States Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz.
Nikolai KlimkoNorth-Western State Medical University named after Iliá Ilich Méchnikov, Saint-Petersburg.
Philipp KoehlerUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne.
Antonio PagliucaDepartment of Hematological Medicine, Kings College Hospital NHS Foundation Trust, London.
Francesco PassamontiDepartment of Medicine and Surgery, University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese.
Oliver A CornelyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging- Associated Diseases (CECAD), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne.
Livio PaganoHematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy Hematology Unit, Università Cattolica del Sacro Cuore, Rome.
EPICOVIDEHA working group
Agostino Gemelli University Polyclinic · ITUniversity of Cologne · DEAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital Universitario Fundación Jiménez Díaz · ESInstitute of Haematology and Blood Transfusion · CZInstituto Português de Oncologia Francisco Gentil · PTMansoura University · EGNorth-Western State Medical University named after I.I. Mechnikov · RUOxford University Hospitals NHS Trust · GBUniversity Hospital Hradec Králové · CZUniversity Medical Center Groningen · NLAga Khan University Hospital · PKAmsterdam University Medical Centers · NLAzerbaijan Scientific-Research & Design-Prospecting Power Engineering Institute · AZAzienda Ospedaliera San Gerardo · ITAzienda Ospedaliera Sant'Andrea · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · IT
Funding
Novel Diagnostic Development for TB Meningitis and HistoplasmosisK23NS110470 · NINDS · UNIVERSITY OF MINNESOTA · PI BAHR, NATHAN · 2019 to 2023
$1.0MNINDS NIH HHS K23 NS110470
Abstract
Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.
Indexed as
COVID-19HematologyLeukemia, Myeloid, AcuteAdultCOVID-19 TestingFollow-Up StudiesHumans
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