Evidence map›Paper›PMID 35545759›Full record

ArticleBMC cardiovascular disorders2022

Is waist-to-height ratio the best predictive indicator of cardiovascular disease incidence in hypertensive adults? A cohort study.

Shu Zhang, Xin Fu, Zhi Du, Xiaofan Guo, Zhao Li, Guozhe Sun, Ying Zhou, Hongmei Yang, Shasha Yu, Liqiang Zheng and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  17. Alcohol and Cannabis Use Associated with Cardiometabolic Biomarkers among "All of Us" Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Shu Zhang *Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Xin Fu *Department of Orthopedics, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China.
Zhi DuDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Xiaofan GuoDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Zhao LiDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Guozhe SunDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Ying ZhouDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Hongmei YangDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Shasha YuDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Liqiang ZhengClinical Epidemiology, Library Shengjing Hospital of China Medical University, Shenyang, China.
Yingxian SunDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
Xingang ZhangDepartment of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China. zhangxingang80@aliyun.com.
China Medical University · CNFirst Hospital of China Medical University · CNShenyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) brings high mortality and economic burden to patients, especially in rural areas. Simple, low-cost abdominal adiposity measures may help identify individuals with increased CVD risk. It is unclear that which obesity indices is the best to predict CVD in hypertensive people.

methodsNortheast China Rural Cardiovascular Health Study (NCRCHS) is a prospective cohort study in a general population in Northeast China. The study examined the cardiovascular health from 2013 to 2015, and follow-up captured the CVD incidence in 2018. Baseline waist-to-height ratio (WHtR), waist circumference (WC), waist-to-hip (WHR)and body mass index (BMI) were calculated and analyzed in relation to the CVD incidence.

resultsA total of 4244 hypertensive adults without pre-existing CVD at baseline were included in this analysis (age 35-92 years; 2108 men). Over a median follow-up of 4.66 years, a total of 290 CVD cases (6.83%) were documented during the follow-up. Baseline WHtR showed a significant positive association with CVD incidence, even after adjusting for age, sex, diabetes, drinking, smoking, SBP, DBP, Triglyceride, HDL-C, LDL-C, and TC (Hazard Ratios per SD of WHtR ranging from 1.03 to 1.31, p = 0.017). Reclassification and discrimination analyses indicated WHtR addition could improve the conventional model for predicting adverse outcomes within 4 years. Moreover, WHtR predicted the CVD incidence better than other obesity indices (BMI, WC, WHR).

conclusionThese findings support a positive association between WHtR and CVD incidence in CVD-free hypertensive adults. WHtR can be used to predict CVD incidence in hypertensive adults.

Indexed as

Cardiovascular DiseasesHypertensionAdultAgedAged, 80 and overBody Mass IndexCohort StudiesHumansIncidenceMaleMiddle AgedObesityProspective StudiesRisk FactorsWaist CircumferenceWaist-Height RatioCardiovascular diseaseHypertensive adultsWHtR

Identifiers

PMID35545759
PMCPMC9092683
OpenAlexW4280534157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.