Evidence map›Paper›PMID 35545727›Full record

ArticlePharmacological reports : PR2022

Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods.

Miao Zhang, Ning Zhang, Xinluan Lu, Wenjin Li, Ruiyong Wang, Junbiao Chang

Abstract read
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In one paragraph

Article in Pharmacological reports : PR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Miao ZhangGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Ning ZhangGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Xinluan LuGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Wenjin LiGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Ruiyong WangGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. wangry@zzu.edu.cn.ORCID http://orcid.org/0000-0002-0524-5934
Junbiao ChangGreen Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. changjunbiao@zzu.edu.cn.
Zhengzhou University · CN

Funding

National Natural Science Foundation of China 82130103National Natural Science Foundation of China U1804283Natural Science Foundation of Henan Province 202300410478
6 · The paper itself

Abstract

As a polyphenolic compound, chlorogenic acid has antioxidant, anti-inflammatory, antiviral, anti-obesity and other effects. Based on the interactions between chlorogenic acid and the proteins (human serum albumin (HSA), pepsin (Pep), trypsin (Try), fat mass and obesity-associated protein (FTO)), results will provide clues for screening effective inhibitors. The interaction between chlorogenic acid and the four proteins (HSA, Pep, Try, FTO) was analyzed by the aid of fluorescence quenching, synchronous fluorescence, three-dimensional fluorescence, isothermal titration calorimetry, and molecular docking. It can be concluded that there is no obvious interaction between chlorogenic acid and FTO. The binding affinity between chlorogenic acid and three proteins is HSA > Try > Pep. The binding process is spontaneous, and the quenching type is static quenching. Hydrophobic interaction and hydrogen bonding is observed in the binding process. This study provides valuable information for understanding the interaction mechanism between chlorogenic acid and proteins, and provides clues for screening inhibitors.

Indexed as

Chlorogenic AcidSerum Albumin, HumanAlpha-Ketoglutarate-Dependent Dioxygenase FTOBinding SitesCalorimetryHumansMolecular Docking SimulationProtein BindingSpectrometry, FluorescenceSpectrum AnalysisAlpha-Ketoglutarate-Dependent Dioxygenase FTOChlorogenic AcidFTO protein, humanSerum Albumin, HumanChlorogenic acidFluorescence spectroscopyIsothermal titration calorimetryMolecular modeling

Identifiers

PMID35545727
OpenAlexW4280495061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.