Evidence map›Paper›PMID 35545644›Full record

Trial reportScientific reports2022

Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury.

Ruyi Huang, Ali A Nikooyan, Lisa D Moore, Sharon Zdunowski, Erika Morikawa, Tiffany Sierro, Dimitry Sayenko, Parag Gad, Tali Homsey, Timothy Le and 9 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Ruyi Huang *Neurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ali A Nikooyan *Neurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Lisa D MooreNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Sharon ZdunowskiDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Erika MorikawaNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Tiffany SierroNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Dimitry SayenkoHouston Methodist Hospital, Houston, TX, 77030, USA.
Parag GadDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Tali HomseyNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Timothy LeNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Meghna A MadhavanNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Marina AbdelshahidNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Martina AbdelshahidNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Yan ZhouNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Mark R NuwerNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Majid SarrafzadehDepartment of Computer Science, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
V Reggie EdgertonBrain Research Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
James C LeiterWhite River Junction VA Medical Center, White River Junction, VT, 05009, USA.
Daniel C LuNeurosurgery Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. dclu@mednet.ucla.edu.
University of California, Los Angeles · USMethodist Hospital · USWhite River Junction VA Medical Center · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCIR01EB007615 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE · 2008 to 2013
$4.9M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIBIB NIH HHS R01 EB007615NIBIB NIH HHS U01 EB015521NIH HHS EB15521NIH HHS UL1TR000124
6 · The paper itself

Abstract

Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined with transcutaneous electrical spinal cord stimulation (tSCS), with or without systemic serotonergic treatment with buspirone (busp), could improve hand function in individuals with severe hand paralysis following SCI, we assessed ten subjects in a double-blind, sham-controlled, crossover study. All treatments-busp, tSCS, and the busp plus tSCS-reduced muscle tone and spasm frequency. Buspirone did not have any discernible impact on grip force or manual dexterity when administered alone or in combination with tSCS. In contrast, grip force, sinusoidal force generation and grip-release rate improved significantly after 6 weeks of tSCS in 5 out of 10 subjects who had residual grip force within the range of 0.1-1.5 N at the baseline evaluation. Improved hand function was sustained in subjects with residual grip force 2-5 months after the tSCS and buspirone treatment. We conclude that tSCS combined with training improves hand strength and manual dexterity in subjects with SCI who have residual grip strength greater than 0.1 N. Buspirone did not significantly improve the hand function nor add to the effect of stimulation.

Indexed as

Spinal Cord InjuriesSpinal Cord StimulationTranscutaneous Electric Nerve StimulationBuspironeCross-Over StudiesHand StrengthHumansSpinal CordBuspirone

Identifiers

PMID35545644
PMCPMC9095635
OpenAlexW4280575713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.