ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2023
Creatine Chemical Exchange Saturation Transfer (Cr-CEST) Imaging Can Evaluate Cisplatin-induced Testicular Damage.
Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Intratesticular creatine maintains spermatogenesis by defining tight junctions.Scientific reports · 2024Article
- Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology.Radiological physics and technology · 2024Review
- Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the ability of creatine-chemical exchange saturation transfer (Cr-CEST) technique assessed through 7-T MRI to evaluate cisplatin-induced testicular damage.
methodsWe used 8-10 weeks C57BL/6 mice (n = 10) that were divided into a control group (n = 5) and a cisplatin-treated group (n = 5). The cisplatin group received cisplatin at a dose of 15 mg/kg, via intraperitoneal injection, while the control group received saline. MR images of mouse testes were acquired under anesthesia 18 days after the injection using a horizontal 7-T scanner. The pulse sequence consisted of rapid acquisition with a relaxation enhancement (RARE) with magnetization transfer. The Z-spectra were collected using a 2000-ms saturation pulse at a B
resultsThe Cr-CEST effect was significantly reduced in the cisplatin-treated group compared to the control group (MTR
conclusionCr-CEST MRI can be useful for the evaluation of cisplatin-induced testicular damage in mice.
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Registered trials
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