Evidence map›Paper›PMID 35545363›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2022

Association of periconceptional folate supplements and

Xinli Song, Peng Huang, Tingting Wang, Senmao Zhang, Letao Chen, Jiabi Qin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinli SongDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078. 1461661756@qq.com.
Peng HuangDepartment of Cardiothoracic Surgery, Hunan Children's Hospital, Changsha 410007, China.
Tingting WangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078.
Senmao ZhangDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078.
Letao ChenDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078.
Jiabi QinDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078. qinjiabi123@163.com.
Hunan Children's Hospital · CN

Funding

Hunan Provincial Key Research and Development Program 2018SK2063Hunan Provincial Science and Technology Talent Support Project 2020TJ-N07Open Project from NHC Key Laboratory of Birth Defect for Research and Prevention KF2020006Postdoctoral Science Foundation 2020M682644the National Natural Science Foundation 82073653 and 81803313
6 · The paper itself

Abstract

objectivesMaternal periconceptional folic acid supplement is by far the most effective primary prevention strategy to reduce the incidence of congenital heart disease (CHD) in offspring. It was revealed that the underlying mechanisms are complex, including a combination of genetic and environmental factors. The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (

methodsA case-control study on 569 mothers of CHD infants and 652 mothers of health controls was performed. The interesting points were periconceptional folate supplements, single nucleotide polymorphisms (SNPs) of maternal

resultsMothers who took folate in the periconceptional period were observed a decreased risk of CHD [adjusted odds ratio (aOR)=0.58, 95% CI 0.35 to 0.95]. Our study also found that polymorphisms of maternal

conclusionsPericonceptional folate supplements, polymorphisms of

Indexed as

Folate Receptor 1Folate Receptor 2Folic AcidHeart Defects, CongenitalCase-Control StudiesDietary SupplementsFemaleHospitalsHumansInfantPolymorphism, Single NucleotideProspective StudiesRisk FactorsFolate Receptor 1Folate Receptor 2Folic AcidFOLR1 protein, humanFOLR2 protein, humancase-control studycongenital heart diseaseFOLR1 geneFOLR2 geneinteraction effects

Identifiers

PMID35545363
PMCPMC10930486
OpenAlexW4280522083

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.