Evidence map›Paper›PMID 35545297›Full record

ArticleBMJ open respiratory research2022

Physiological changes related to 10 weeks of singing for lung health in patients with COPD.

Mette Kaasgaard, Daniel Bech Rasmussen, Anders Løkke, Peter Vuust, Ole Hilberg, Uffe Bodtger

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03280355 nacompletednot on this map

The Effects of Singing Training for Patients With Chronic Obstructive Pulmonary Disease (COPD)

TypeinterventionalSponsorUniversity of AarhusRan2017 to 2019Enrolled270ConditionsChronic Obstructive Pulmonary DiseaseArmsSinging training, Physical Training
NCT07460999 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effects and Mechanisms of Online Delivered Singing Training vs Usual Care in Patients With Persistent Symptoms 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC) - a Multi-centre RCT

TypeinterventionalSponsorZealand University HospitalRan2026 to 2027Enrolled100ConditionsNon-Small Cell Lung Cancer, Chronic Obstructive Lung DiseaseArmsSinging training (Singing for Lung Health (SLH)), Control group: Usual care
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Effect of Singing on Symptoms in Stable COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2022
    Pooled it
  2. Trial
  3. Article
  4. Observational
  5. Singing for adults with chronic respiratory disease.The Cochrane database of systematic reviews · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mette KaasgaardCenter for Music in the Brain, Department of Clinical Medicine, Aarhus University and the Royal Academy of Music, Aarhus/Aalborg, Aarhus University, Faculty of Health, Aarhus, Denmark mk@clin.au.dk.
Daniel Bech RasmussenPulmonary Research Unit Region Zealand (PLUZ), Department of Respiratory Medicine, Zealand Univsersity Hospital Naestved and Roskilde, Naestved, Denmark.
Anders LøkkeDepartment of Regional Health Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Peter VuustCenter for Music in the Brain, Department of Clinical Medicine, Aarhus University and the Royal Academy of Music, Aarhus/Aalborg, Aarhus University, Faculty of Health, Aarhus, Denmark.
Ole HilbergDepartment of Regional Health Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Uffe BodtgerPulmonary Research Unit Region Zealand (PLUZ), Department of Respiratory Medicine, Zealand Univsersity Hospital Naestved and Roskilde, Naestved, Denmark.
Lillebaelt Hospital · DKUniversity of Southern Denmark · DKAarhus University · DKRoyal Academy of Music · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSinging for Lung Health (SLH) was non-inferior to physical exercise training in improving 6-minute walking test distance (6MWD) and quality of life (St. George's Respiratory Questionnaire (SGRQ)) within a 10-week pulmonary rehabilitation (PR) programme for COPD in our recent randomised controlled trial (RCT) (NCT03280355). Previous studies suggest that singing improves lung function, respiratory control and dyspnoea, however this has not yet been convincingly confirmed. Therefore, this study aimed to explore the impact of SLH on physiological parameters and the associations with achieving the minimal important difference (MID) in 6MWD and/or SGRQ.

methodsWe conducted post hoc, per-protocol analyses mainly of the SLH group of the RCT, exploring associations with 6MWD and SGRQ results by stratifying into achieving versus not-achieving 6MWD-MID (≥30 m) and SGRQ-MID (

resultsIn the SLH study group (n=108), 6MWD-MID was achieved by 31/108 (29%) and in SGRQ by 53/108 (49%). Baseline factors associated with achieving MID in either outcome included short baseline 6MWD and high body mass index. Achieving 6MWD-MID was correlated with improved heart rate response (OR: 3.14; p=0.03) and achieving SGRQ-MID was correlated with improved maximal inspiratory pressure (OR: 4.35; p=0.04). Neither outcome was correlated with significant spirometric changes. Agreement in achieving both 6MWD-MID and SGRQ-MID was surprisingly insignificant.

conclusionsThis explorative post hoc study suggests that SLH is associated with physiological changes after short-term PR for COPD. Future physiological studies will help us to understand the mechanisms of singing in COPD. Our study furthermore raises concern about poor agreement between subjective and objective benefits of PR despite state-of-the-art tools.

Indexed as

Pulmonary Disease, Chronic ObstructiveSingingDyspneaHumansLungQuality of Lifeemphysemaexerciselung physiologypulmonary rehabilitationrespiratory muscles

Identifiers

PMID35545297
PMCPMC9096537
OpenAlexW4280595232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.