Evidence map›Paper›PMID 35545295›Full record

ArticleLife science alliance2022

OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection.

Elinor Hortle, Vi Lt Tran, Kathryn Wright, Angela Rm Fontaine, Natalia Pinello, Matthew B O'Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Inflammasomes in respiratory diseases: from disease pathogenesis to drug development and use of multi-omics.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. One Host-Multiple Applications: Zebrafish (International journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Elinor HortleTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia e.hortle@centenary.org.au stefan_oehlers@idlabs.a-star.edu.sg.ORCID 0000-0001-9633-5638
Vi Lt TranTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia.
Kathryn WrightTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia.ORCID 0000-0001-6508-3386
Angela Rm FontaineCentenary Imaging and Sydney Cytometry at the Centenary Institute, The University of Sydney, Camperdown, Australia.ORCID 0000-0002-5032-8026
Natalia PinelloEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, Australia.ORCID 0000-0003-3514-6627
Matthew B O'RourkeCentre for Inflammation and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia.
Justin J-L WongEpigenetics and RNA Biology Program Centenary Institute, The University of Sydney, Camperdown, Australia.ORCID 0000-0002-7038-5079
Philip M HansbroCentre for Inflammation and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia.
Warwick J BrittonTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia.
Stefan H OehlersTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, Australia e.hortle@centenary.org.au stefan_oehlers@idlabs.a-star.edu.sg.ORCID 0000-0003-0260-672X
The University of Sydney · AUUniversity of Technology Sydney · AUAgency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic mycobacteria inhibit inflammasome activation to establish infection. Although it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux, and inflammasome activation has not been investigated. Here, we use

Indexed as

InflammasomesMycobacteriumAnimalsNLR Family, Pyrin Domain-Containing 3 ProteinPotassiumSignal TransductionZebrafishInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPotassium

Identifiers

PMID35545295
PMCPMC9107790
OpenAlexW4280567316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.